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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSO
All Species:
17.88
Human Site:
S208
Identified Species:
30.26
UniProt:
P43234
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43234
NP_001325.1
321
35958
S208
N
G
L
C
H
Y
F
S
G
S
H
S
G
F
S
Chimpanzee
Pan troglodytes
XP_517502
318
35542
S205
N
G
L
C
H
Y
F
S
G
S
H
S
G
F
S
Rhesus Macaque
Macaca mulatta
XP_001093045
321
35995
S208
N
G
L
C
H
Y
F
S
G
S
H
S
G
F
S
Dog
Lupus familis
XP_539782
518
56900
S403
N
G
L
C
H
Y
F
S
D
S
Y
S
G
F
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8BM88
312
34705
P199
N
G
Q
C
R
H
F
P
Q
S
Q
A
G
V
S
Rat
Rattus norvegicus
P07154
334
37642
A215
D
G
S
C
K
Y
R
A
E
Y
A
V
A
N
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510786
301
33355
S188
T
G
I
C
H
Y
F
S
G
S
H
Y
G
I
S
Chicken
Gallus gallus
NP_001026300
320
35009
P207
T
G
L
C
H
Y
F
P
H
S
D
F
G
V
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_695717
334
36928
P221
D
G
V
C
Q
F
F
P
Q
A
H
A
G
V
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VN93
614
68942
V500
R
T
L
S
H
V
Q
V
A
G
F
V
D
L
P
Honey Bee
Apis mellifera
XP_623690
374
42365
K260
K
L
G
K
M
T
D
K
T
F
N
I
K
I
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_798313
331
37336
Y218
S
L
V
P
E
S
T
Y
P
Y
I
A
K
K
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q10716
371
40329
K242
T
G
S
D
G
K
C
K
F
D
K
S
K
I
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43296
368
40400
V248
K
L
D
K
S
K
I
V
A
S
V
S
N
F
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.7
95
51.9
N.A.
71.6
30.2
N.A.
69.1
65.7
N.A.
50.2
N.A.
20.2
34.7
N.A.
40.4
Protein Similarity:
100
99
95.9
55.7
N.A.
80.6
46.7
N.A.
79.1
76
N.A.
66.7
N.A.
32.5
52.9
N.A.
56.8
P-Site Identity:
100
100
100
86.6
N.A.
46.6
20
N.A.
73.3
60
N.A.
33.3
N.A.
13.3
0
N.A.
0
P-Site Similarity:
100
100
100
93.3
N.A.
60
33.3
N.A.
80
60
N.A.
73.3
N.A.
13.3
6.6
N.A.
20
Percent
Protein Identity:
N.A.
30.4
N.A.
29
N.A.
N.A.
Protein Similarity:
N.A.
46.6
N.A.
47.8
N.A.
N.A.
P-Site Identity:
N.A.
13.3
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
8
15
8
8
22
8
0
8
% A
% Cys:
0
0
0
65
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
15
0
8
8
0
0
8
0
8
8
8
0
8
0
8
% D
% Glu:
0
0
0
0
8
0
0
0
8
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
8
58
0
8
8
8
8
0
36
0
% F
% Gly:
0
72
8
0
8
0
0
0
29
8
0
0
58
0
8
% G
% His:
0
0
0
0
50
8
0
0
8
0
36
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
8
0
0
0
8
8
0
22
0
% I
% Lys:
15
0
0
15
8
15
0
15
0
0
8
0
22
8
0
% K
% Leu:
0
22
43
0
0
0
0
0
0
0
0
0
0
8
0
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
36
0
0
0
0
0
0
0
0
0
8
0
8
8
0
% N
% Pro:
0
0
0
8
0
0
0
22
8
0
0
0
0
0
8
% P
% Gln:
0
0
8
0
8
0
8
0
15
0
8
0
0
0
8
% Q
% Arg:
8
0
0
0
8
0
8
0
0
0
0
0
0
0
0
% R
% Ser:
8
0
15
8
8
8
0
36
0
58
0
43
0
0
58
% S
% Thr:
22
8
0
0
0
8
8
0
8
0
0
0
0
0
0
% T
% Val:
0
0
15
0
0
8
0
15
0
0
8
15
0
22
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
50
0
8
0
15
8
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _