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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CTSO All Species: 24.55
Human Site: S215 Identified Species: 41.54
UniProt: P43234 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P43234 NP_001325.1 321 35958 S215 S G S H S G F S I K G Y S A Y
Chimpanzee Pan troglodytes XP_517502 318 35542 S212 S G S H S G F S I K G Y S A Y
Rhesus Macaque Macaca mulatta XP_001093045 321 35995 S215 S G S H S G F S I K G Y S A Y
Dog Lupus familis XP_539782 518 56900 S410 S D S Y S G F S I R G Y S A Y
Cat Felis silvestris
Mouse Mus musculus Q8BM88 312 34705 S206 P Q S Q A G V S V K D F S A Y
Rat Rattus norvegicus P07154 334 37642 D222 A E Y A V A N D T G F V D I P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510786 301 33355 S195 S G S H Y G I S I R G Y S A Y
Chicken Gallus gallus NP_001026300 320 35009 S214 P H S D F G V S I T G F A A Y
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_695717 334 36928 A228 P Q A H A G V A V R N Y S A Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VN93 614 68942 P507 V A G F V D L P K G N E T A M
Honey Bee Apis mellifera XP_623690 374 42365 Q267 K T F N I K I Q D F T C D S F
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_798313 331 37336 G225 Y P Y I A K K G D C R I N K N
Poplar Tree Populus trichocarpa
Maize Zea mays Q10716 371 40329 V249 K F D K S K I V A S V Q N F S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43296 368 40400 S255 V A S V S N F S V I S I D E E
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.7 95 51.9 N.A. 71.6 30.2 N.A. 69.1 65.7 N.A. 50.2 N.A. 20.2 34.7 N.A. 40.4
Protein Similarity: 100 99 95.9 55.7 N.A. 80.6 46.7 N.A. 79.1 76 N.A. 66.7 N.A. 32.5 52.9 N.A. 56.8
P-Site Identity: 100 100 100 80 N.A. 46.6 0 N.A. 80 46.6 N.A. 40 N.A. 6.6 0 N.A. 0
P-Site Similarity: 100 100 100 93.3 N.A. 66.6 6.6 N.A. 86.6 60 N.A. 73.3 N.A. 13.3 20 N.A. 13.3
Percent
Protein Identity: N.A. 30.4 N.A. 29 N.A. N.A.
Protein Similarity: N.A. 46.6 N.A. 47.8 N.A. N.A.
P-Site Identity: N.A. 6.6 N.A. 26.6 N.A. N.A.
P-Site Similarity: N.A. 13.3 N.A. 33.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 15 8 8 22 8 0 8 8 0 0 0 8 65 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 8 0 8 0 0 0 % C
% Asp: 0 8 8 8 0 8 0 8 15 0 8 0 22 0 0 % D
% Glu: 0 8 0 0 0 0 0 0 0 0 0 8 0 8 8 % E
% Phe: 0 8 8 8 8 0 36 0 0 8 8 15 0 8 8 % F
% Gly: 0 29 8 0 0 58 0 8 0 15 43 0 0 0 0 % G
% His: 0 8 0 36 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 8 8 0 22 0 43 8 0 15 0 8 0 % I
% Lys: 15 0 0 8 0 22 8 0 8 29 0 0 0 8 0 % K
% Leu: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % M
% Asn: 0 0 0 8 0 8 8 0 0 0 15 0 15 0 8 % N
% Pro: 22 8 0 0 0 0 0 8 0 0 0 0 0 0 8 % P
% Gln: 0 15 0 8 0 0 0 8 0 0 0 8 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 22 8 0 0 0 0 % R
% Ser: 36 0 58 0 43 0 0 58 0 8 8 0 50 8 8 % S
% Thr: 0 8 0 0 0 0 0 0 8 8 8 0 8 0 0 % T
% Val: 15 0 0 8 15 0 22 8 22 0 8 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 15 8 8 0 0 0 0 0 0 43 0 0 58 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _