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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSO
All Species:
22.42
Human Site:
Y145
Identified Species:
37.95
UniProt:
P43234
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43234
NP_001325.1
321
35958
Y145
V
G
A
V
E
S
A
Y
A
I
K
G
K
P
L
Chimpanzee
Pan troglodytes
XP_517502
318
35542
Y142
V
G
A
V
E
S
A
Y
A
I
K
G
K
P
L
Rhesus Macaque
Macaca mulatta
XP_001093045
321
35995
Y145
V
G
A
V
E
S
A
Y
A
I
K
G
K
P
L
Dog
Lupus familis
XP_539782
518
56900
Y340
V
G
A
V
E
S
A
Y
A
I
K
G
K
P
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8BM88
312
34705
R136
V
S
A
I
E
S
A
R
A
I
Q
G
K
S
L
Rat
Rattus norvegicus
P07154
334
37642
M151
S
G
C
L
E
G
Q
M
F
L
K
T
G
K
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510786
301
33355
R128
I
E
S
A
Y
A
I
R
G
K
P
L
E
E
L
Chicken
Gallus gallus
NP_001026300
320
35009
Y144
V
G
G
I
E
S
A
Y
A
I
K
G
H
N
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_695717
334
36928
S158
V
E
A
I
E
S
V
S
A
K
G
G
E
K
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VN93
614
68942
Y431
T
G
N
I
E
G
L
Y
A
V
K
T
G
E
L
Honey Bee
Apis mellifera
XP_623690
374
42365
F192
I
E
V
I
E
S
M
F
A
I
K
N
G
T
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_798313
331
37336
A155
K
S
C
G
A
C
W
A
F
S
V
V
E
T
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q10716
371
40329
H174
S
G
A
L
E
G
A
H
Y
L
A
T
G
K
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43296
368
40400
N172
T
G
A
L
E
G
A
N
F
L
A
T
G
K
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.7
95
51.9
N.A.
71.6
30.2
N.A.
69.1
65.7
N.A.
50.2
N.A.
20.2
34.7
N.A.
40.4
Protein Similarity:
100
99
95.9
55.7
N.A.
80.6
46.7
N.A.
79.1
76
N.A.
66.7
N.A.
32.5
52.9
N.A.
56.8
P-Site Identity:
100
100
100
100
N.A.
66.6
26.6
N.A.
6.6
73.3
N.A.
46.6
N.A.
40
40
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
80
40
N.A.
33.3
80
N.A.
60
N.A.
53.3
60
N.A.
13.3
Percent
Protein Identity:
N.A.
30.4
N.A.
29
N.A.
N.A.
Protein Similarity:
N.A.
46.6
N.A.
47.8
N.A.
N.A.
P-Site Identity:
N.A.
33.3
N.A.
33.3
N.A.
N.A.
P-Site Similarity:
N.A.
53.3
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
58
8
8
8
58
8
65
0
15
0
0
0
0
% A
% Cys:
0
0
15
0
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
22
0
0
86
0
0
0
0
0
0
0
22
15
0
% E
% Phe:
0
0
0
0
0
0
0
8
22
0
0
0
0
0
0
% F
% Gly:
0
65
8
8
0
29
0
0
8
0
8
50
36
0
0
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% H
% Ile:
15
0
0
36
0
0
8
0
0
50
0
0
0
0
0
% I
% Lys:
8
0
0
0
0
0
0
0
0
15
58
0
36
29
0
% K
% Leu:
0
0
0
22
0
0
8
0
0
22
0
8
0
0
93
% L
% Met:
0
0
0
0
0
0
8
8
0
0
0
0
0
0
8
% M
% Asn:
0
0
8
0
0
0
0
8
0
0
0
8
0
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
8
0
0
29
0
% P
% Gln:
0
0
0
0
0
0
8
0
0
0
8
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
15
0
0
0
0
0
0
0
% R
% Ser:
15
15
8
0
0
58
0
8
0
8
0
0
0
8
0
% S
% Thr:
15
0
0
0
0
0
0
0
0
0
0
29
0
15
0
% T
% Val:
50
0
8
29
0
0
8
0
0
8
8
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
43
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _