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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSO
All Species:
25.45
Human Site:
Y168
Identified Species:
43.08
UniProt:
P43234
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43234
NP_001325.1
321
35958
Y168
I
D
C
S
Y
N
N
Y
G
C
N
G
G
S
T
Chimpanzee
Pan troglodytes
XP_517502
318
35542
Y165
I
D
C
S
Y
N
N
Y
G
C
N
G
G
S
T
Rhesus Macaque
Macaca mulatta
XP_001093045
321
35995
Y168
I
D
C
S
Y
T
N
Y
G
C
N
G
G
S
T
Dog
Lupus familis
XP_539782
518
56900
Y363
I
D
C
S
Y
N
N
Y
G
C
S
G
G
S
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8BM88
312
34705
S159
I
D
C
S
F
N
N
S
G
C
L
G
G
S
P
Rat
Rattus norvegicus
P07154
334
37642
G174
V
D
C
S
H
D
Q
G
N
Q
G
C
N
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510786
301
33355
S151
S
Y
N
N
F
G
C
S
G
G
S
T
I
N
A
Chicken
Gallus gallus
NP_001026300
320
35009
Y167
I
D
C
S
Y
S
N
Y
G
C
S
G
G
S
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_695717
334
36928
Q181
I
D
C
S
Y
Q
N
Q
G
C
N
G
G
S
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VN93
614
68942
S454
L
D
C
D
T
T
D
S
A
C
N
G
G
L
M
Honey Bee
Apis mellifera
XP_623690
374
42365
N215
I
D
C
A
K
N
S
N
F
G
C
E
G
G
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_798313
331
37336
A178
K
R
L
T
Q
L
S
A
Q
E
L
V
D
C
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q10716
371
40329
D197
V
D
C
D
H
E
C
D
S
S
E
P
D
S
C
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43296
368
40400
D195
V
D
C
D
H
E
C
D
P
E
E
A
D
S
C
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.7
95
51.9
N.A.
71.6
30.2
N.A.
69.1
65.7
N.A.
50.2
N.A.
20.2
34.7
N.A.
40.4
Protein Similarity:
100
99
95.9
55.7
N.A.
80.6
46.7
N.A.
79.1
76
N.A.
66.7
N.A.
32.5
52.9
N.A.
56.8
P-Site Identity:
100
100
93.3
93.3
N.A.
73.3
20
N.A.
6.6
86.6
N.A.
80
N.A.
40
33.3
N.A.
0
P-Site Similarity:
100
100
93.3
100
N.A.
80
40
N.A.
33.3
100
N.A.
80
N.A.
53.3
46.6
N.A.
13.3
Percent
Protein Identity:
N.A.
30.4
N.A.
29
N.A.
N.A.
Protein Similarity:
N.A.
46.6
N.A.
47.8
N.A.
N.A.
P-Site Identity:
N.A.
20
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
8
8
0
0
8
0
0
8
% A
% Cys:
0
0
86
0
0
0
22
0
0
58
8
8
0
8
15
% C
% Asp:
0
86
0
22
0
8
8
15
0
0
0
0
22
0
8
% D
% Glu:
0
0
0
0
0
15
0
0
0
15
15
8
0
0
0
% E
% Phe:
0
0
0
0
15
0
0
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
8
0
8
58
15
8
58
65
15
15
% G
% His:
0
0
0
0
22
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
58
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% I
% Lys:
8
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
8
0
8
0
0
8
0
0
0
0
15
0
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
8
8
0
36
50
8
8
0
36
0
8
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
8
0
0
8
0
0
15
% P
% Gln:
0
0
0
0
8
8
8
8
8
8
0
0
0
0
0
% Q
% Arg:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
8
0
0
58
0
8
15
22
8
8
22
0
0
65
0
% S
% Thr:
0
0
0
8
8
15
0
0
0
0
0
8
0
0
36
% T
% Val:
22
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
43
0
0
36
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _