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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSO
All Species:
23.64
Human Site:
Y74
Identified Species:
40
UniProt:
P43234
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43234
NP_001325.1
321
35958
Y74
Y
G
I
N
Q
F
S
Y
L
F
P
E
E
F
K
Chimpanzee
Pan troglodytes
XP_517502
318
35542
Y71
Y
G
I
N
Q
F
S
Y
L
F
P
E
E
F
K
Rhesus Macaque
Macaca mulatta
XP_001093045
321
35995
Y74
Y
G
I
N
Q
F
S
Y
L
F
P
E
E
F
K
Dog
Lupus familis
XP_539782
518
56900
Y269
Y
G
I
N
Q
F
S
Y
L
S
P
E
E
F
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8BM88
312
34705
Y65
Y
G
V
N
Q
F
S
Y
L
F
P
E
E
F
K
Rat
Rattus norvegicus
P07154
334
37642
F80
F
T
M
E
M
N
A
F
G
D
M
T
N
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510786
301
33355
P57
N
Q
F
S
Y
L
F
P
E
E
F
K
A
I
Y
Chicken
Gallus gallus
NP_001026300
320
35009
F73
A
F
Y
G
K
N
Q
F
S
H
L
F
P
E
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_695717
334
36928
Y87
Y
G
V
N
Q
F
S
Y
L
S
Q
K
Q
F
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VN93
614
68942
M360
G
I
T
E
F
A
D
M
T
S
S
E
Y
K
E
Honey Bee
Apis mellifera
XP_623690
374
42365
T121
E
N
E
F
L
L
H
T
L
L
P
D
L
P
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_798313
331
37336
T84
A
T
H
R
D
H
A
T
Y
G
I
T
K
F
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q10716
371
40329
E103
F
S
D
L
T
P
A
E
F
R
R
T
Y
L
G
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43296
368
40400
D101
H
G
V
T
Q
F
S
D
L
T
R
S
E
F
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.7
95
51.9
N.A.
71.6
30.2
N.A.
69.1
65.7
N.A.
50.2
N.A.
20.2
34.7
N.A.
40.4
Protein Similarity:
100
99
95.9
55.7
N.A.
80.6
46.7
N.A.
79.1
76
N.A.
66.7
N.A.
32.5
52.9
N.A.
56.8
P-Site Identity:
100
100
100
93.3
N.A.
93.3
0
N.A.
0
0
N.A.
66.6
N.A.
6.6
13.3
N.A.
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
100
33.3
N.A.
13.3
20
N.A.
86.6
N.A.
13.3
20
N.A.
20
Percent
Protein Identity:
N.A.
30.4
N.A.
29
N.A.
N.A.
Protein Similarity:
N.A.
46.6
N.A.
47.8
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
46.6
N.A.
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
66.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
0
0
0
8
22
0
0
0
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
8
0
8
8
0
8
0
8
0
0
0
% D
% Glu:
8
0
8
15
0
0
0
8
8
8
0
43
43
15
22
% E
% Phe:
15
8
8
8
8
50
8
15
8
29
8
8
0
58
0
% F
% Gly:
8
50
0
8
0
0
0
0
8
8
0
0
0
0
8
% G
% His:
8
0
8
0
0
8
8
0
0
8
0
0
0
0
0
% H
% Ile:
0
8
29
0
0
0
0
0
0
0
8
0
0
8
8
% I
% Lys:
0
0
0
0
8
0
0
0
0
0
0
15
8
8
43
% K
% Leu:
0
0
0
8
8
15
0
0
58
8
8
0
8
8
0
% L
% Met:
0
0
8
0
8
0
0
8
0
0
8
0
0
0
0
% M
% Asn:
8
8
0
43
0
15
0
0
0
0
0
0
8
0
0
% N
% Pro:
0
0
0
0
0
8
0
8
0
0
43
0
8
8
0
% P
% Gln:
0
8
0
0
50
0
8
0
0
0
8
0
8
0
0
% Q
% Arg:
0
0
0
8
0
0
0
0
0
8
15
0
0
0
8
% R
% Ser:
0
8
0
8
0
0
50
0
8
22
8
8
0
0
8
% S
% Thr:
0
15
8
8
8
0
0
15
8
8
0
22
0
0
0
% T
% Val:
0
0
22
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
43
0
8
0
8
0
0
43
8
0
0
0
15
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _