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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH2
All Species:
27.88
Human Site:
S473
Identified Species:
55.76
UniProt:
P43246
Number Species:
11
Phosphosite Substitution
Charge Score:
0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43246
NP_000242.1
934
104743
S473
H
E
F
L
V
K
P
S
F
D
P
N
L
S
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_538482
934
104744
S473
H
E
F
L
V
K
P
S
F
D
P
N
L
S
E
Cat
Felis silvestris
Mouse
Mus musculus
P43247
935
104133
S473
H
E
F
L
V
K
P
S
F
D
P
N
L
S
E
Rat
Rattus norvegicus
P54275
933
104009
S473
H
E
F
L
V
K
P
S
F
D
P
N
L
S
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_426110
919
102741
S459
H
E
F
L
V
K
A
S
F
D
P
N
L
T
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_998689
936
103778
S473
H
E
F
L
V
K
P
S
F
D
P
T
L
S
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P43248
917
103294
S471
G
E
Y
L
V
K
A
S
F
D
S
R
L
M
E
Honey Bee
Apis mellifera
XP_001121207
890
100774
E444
G
D
F
L
V
R
P
E
F
D
D
E
L
K
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9XGC9
942
105052
L470
G
E
Y
R
I
S
P
L
Y
S
S
D
L
G
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O24617
937
105485
S468
G
E
Y
M
I
S
S
S
Y
D
T
K
L
A
S
Baker's Yeast
Sacchar. cerevisiae
P25847
964
108866
E491
N
E
F
M
I
K
V
E
F
N
E
E
L
G
K
Red Bread Mold
Neurospora crassa
O13396
937
105050
E463
H
E
F
I
I
K
P
E
F
D
D
S
L
R
I
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
96.1
N.A.
92.4
91.4
N.A.
N.A.
76.3
N.A.
71.9
N.A.
42.8
46.9
N.A.
N.A.
Protein Similarity:
100
N.A.
N.A.
98.3
N.A.
96.3
96.2
N.A.
N.A.
87.2
N.A.
88.2
N.A.
63.1
66.6
N.A.
N.A.
P-Site Identity:
100
N.A.
N.A.
100
N.A.
100
100
N.A.
N.A.
86.6
N.A.
86.6
N.A.
60
53.3
N.A.
N.A.
P-Site Similarity:
100
N.A.
N.A.
100
N.A.
100
100
N.A.
N.A.
93.3
N.A.
93.3
N.A.
66.6
66.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
42.1
N.A.
41.8
40.3
47.6
Protein Similarity:
N.A.
62.9
N.A.
62.5
62
65.6
P-Site Identity:
N.A.
20
N.A.
26.6
33.3
53.3
P-Site Similarity:
N.A.
46.6
N.A.
60
66.6
73.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
17
0
0
0
0
0
0
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
0
0
0
0
0
0
0
84
17
9
0
0
9
% D
% Glu:
0
92
0
0
0
0
0
25
0
0
9
17
0
0
59
% E
% Phe:
0
0
75
0
0
0
0
0
84
0
0
0
0
0
0
% F
% Gly:
34
0
0
0
0
0
0
0
0
0
0
0
0
17
0
% G
% His:
59
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
9
34
0
0
0
0
0
0
0
0
0
9
% I
% Lys:
0
0
0
0
0
75
0
0
0
0
0
9
0
9
9
% K
% Leu:
0
0
0
67
0
0
0
9
0
0
0
0
100
0
0
% L
% Met:
0
0
0
17
0
0
0
0
0
0
0
0
0
9
0
% M
% Asn:
9
0
0
0
0
0
0
0
0
9
0
42
0
0
0
% N
% Pro:
0
0
0
0
0
0
67
0
0
0
50
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
9
0
9
0
0
0
0
0
9
0
9
0
% R
% Ser:
0
0
0
0
0
17
9
67
0
9
17
9
0
42
9
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
9
9
0
9
0
% T
% Val:
0
0
0
0
67
0
9
0
0
0
0
0
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
25
0
0
0
0
0
17
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _