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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MSH2 All Species: 18.79
Human Site: S494 Identified Species: 37.58
UniProt: P43246 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P43246 NP_000242.1 934 104743 S494 D L E K K M Q S T L I S A A R
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_538482 934 104744 S494 D L E K K M Q S T L I S A A R
Cat Felis silvestris
Mouse Mus musculus P43247 935 104133 S494 G L E K K M Q S T L I N A A R
Rat Rattus norvegicus P54275 933 104009 S494 G L E K K M Q S T L I S A A R
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_426110 919 102741 T480 E L E E S M Q T L L K S A A K
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_998689 936 103778 A494 R L E K A M Q A A L S S A A R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P43248 917 103294 E492 E L Y S K M E E L Q F K C S Q
Honey Bee Apis mellifera XP_001121207 890 100774 A465 E I E I K L Q A Q L N K V A D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays Q9XGC9 942 105052 N491 V V E N H I N N L H V D T A S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O24617 937 105485 E489 L L E Q Q I H E L H K K T A I
Baker's Yeast Sacchar. cerevisiae P25847 964 108866 S512 T L R D E I H S I H L D S A E
Red Bread Mold Neurospora crassa O13396 937 105050 N484 R L R T D M D N E F A E A A E
Conservation
Percent
Protein Identity: 100 N.A. N.A. 96.1 N.A. 92.4 91.4 N.A. N.A. 76.3 N.A. 71.9 N.A. 42.8 46.9 N.A. N.A.
Protein Similarity: 100 N.A. N.A. 98.3 N.A. 96.3 96.2 N.A. N.A. 87.2 N.A. 88.2 N.A. 63.1 66.6 N.A. N.A.
P-Site Identity: 100 N.A. N.A. 100 N.A. 86.6 93.3 N.A. N.A. 53.3 N.A. 66.6 N.A. 20 33.3 N.A. N.A.
P-Site Similarity: 100 N.A. N.A. 100 N.A. 93.3 93.3 N.A. N.A. 80 N.A. 73.3 N.A. 46.6 60 N.A. N.A.
Percent
Protein Identity: N.A. 42.1 N.A. 41.8 40.3 47.6
Protein Similarity: N.A. 62.9 N.A. 62.5 62 65.6
P-Site Identity: N.A. 13.3 N.A. 20 20 26.6
P-Site Similarity: N.A. 40 N.A. 40 46.6 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 9 0 0 17 9 0 9 0 59 92 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % C
% Asp: 17 0 0 9 9 0 9 0 0 0 0 17 0 0 9 % D
% Glu: 25 0 75 9 9 0 9 17 9 0 0 9 0 0 17 % E
% Phe: 0 0 0 0 0 0 0 0 0 9 9 0 0 0 0 % F
% Gly: 17 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 9 0 17 0 0 25 0 0 0 0 0 % H
% Ile: 0 9 0 9 0 25 0 0 9 0 34 0 0 0 9 % I
% Lys: 0 0 0 42 50 0 0 0 0 0 17 25 0 0 9 % K
% Leu: 9 84 0 0 0 9 0 0 34 59 9 0 0 0 0 % L
% Met: 0 0 0 0 0 67 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 9 0 0 9 17 0 0 9 9 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 9 9 0 59 0 9 9 0 0 0 0 9 % Q
% Arg: 17 0 17 0 0 0 0 0 0 0 0 0 0 0 42 % R
% Ser: 0 0 0 9 9 0 0 42 0 0 9 42 9 9 9 % S
% Thr: 9 0 0 9 0 0 0 9 34 0 0 0 17 0 0 % T
% Val: 9 9 0 0 0 0 0 0 0 0 9 0 9 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _