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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH2
All Species:
30.61
Human Site:
S554
Identified Species:
61.21
UniProt:
P43246
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43246
NP_000242.1
934
104743
S554
N
G
V
K
F
T
N
S
K
L
T
S
L
N
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_538482
934
104744
S554
N
G
V
K
F
T
N
S
K
L
T
S
L
N
E
Cat
Felis silvestris
Mouse
Mus musculus
P43247
935
104133
S554
N
G
V
K
F
T
N
S
E
L
S
S
L
N
E
Rat
Rattus norvegicus
P54275
933
104009
S554
N
G
V
K
F
T
N
S
E
L
S
S
L
N
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_426110
919
102741
S540
N
G
V
K
F
T
N
S
K
L
S
A
I
N
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_998689
936
103778
S554
N
G
V
R
F
T
N
S
K
L
S
S
L
N
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P43248
917
103294
D552
G
G
V
R
F
T
S
D
K
L
E
G
Y
A
D
Honey Bee
Apis mellifera
XP_001121207
890
100774
N525
S
G
V
R
F
R
S
N
K
L
N
D
L
N
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9XGC9
942
105052
S552
D
G
V
K
F
T
N
S
K
L
K
N
L
S
D
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O24617
937
105485
T551
D
G
V
K
F
T
N
T
K
L
K
K
L
G
D
Baker's Yeast
Sacchar. cerevisiae
P25847
964
108866
K572
A
G
I
F
F
S
T
K
Q
L
K
S
I
A
N
Red Bread Mold
Neurospora crassa
O13396
937
105050
K544
N
G
V
Y
F
T
T
K
T
L
Q
A
L
R
R
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
96.1
N.A.
92.4
91.4
N.A.
N.A.
76.3
N.A.
71.9
N.A.
42.8
46.9
N.A.
N.A.
Protein Similarity:
100
N.A.
N.A.
98.3
N.A.
96.3
96.2
N.A.
N.A.
87.2
N.A.
88.2
N.A.
63.1
66.6
N.A.
N.A.
P-Site Identity:
100
N.A.
N.A.
100
N.A.
86.6
86.6
N.A.
N.A.
80
N.A.
86.6
N.A.
40
46.6
N.A.
N.A.
P-Site Similarity:
100
N.A.
N.A.
100
N.A.
100
100
N.A.
N.A.
100
N.A.
100
N.A.
60
80
N.A.
N.A.
Percent
Protein Identity:
N.A.
42.1
N.A.
41.8
40.3
47.6
Protein Similarity:
N.A.
62.9
N.A.
62.5
62
65.6
P-Site Identity:
N.A.
66.6
N.A.
60
26.6
46.6
P-Site Similarity:
N.A.
93.3
N.A.
80
53.3
53.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
0
0
0
0
0
0
0
17
0
17
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
17
0
0
0
0
0
0
9
0
0
0
9
0
0
34
% D
% Glu:
0
0
0
0
0
0
0
0
17
0
9
0
0
0
50
% E
% Phe:
0
0
0
9
100
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
9
100
0
0
0
0
0
0
0
0
0
9
0
9
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
9
0
0
0
0
0
0
0
0
0
17
0
0
% I
% Lys:
0
0
0
59
0
0
0
17
67
0
25
9
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
100
0
0
75
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
59
0
0
0
0
0
67
9
0
0
9
9
0
59
9
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
9
0
9
0
0
0
0
% Q
% Arg:
0
0
0
25
0
9
0
0
0
0
0
0
0
9
9
% R
% Ser:
9
0
0
0
0
9
17
59
0
0
34
50
0
9
0
% S
% Thr:
0
0
0
0
0
84
17
9
9
0
17
0
0
0
0
% T
% Val:
0
0
92
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
9
0
0
0
0
0
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _