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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MSH2 All Species: 19.39
Human Site: T375 Identified Species: 38.79
UniProt: P43246 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P43246 NP_000242.1 934 104743 T375 E D A E L R Q T L Q E D L L R
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_538482 934 104744 S375 E D A E L R Q S L Q E D L L R
Cat Felis silvestris
Mouse Mus musculus P43247 935 104133 S375 E D S E L R Q S L Q E D L L R
Rat Rattus norvegicus P54275 933 104009 A375 E D S E L R R A L Q E D L L R
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_426110 919 102741 G361 V D T E L R Q G L Q E D L L R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_998689 936 103778 S375 E D S E L R K S C Q E D L L R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P43248 917 103294 T376 E S P D T M E T L S L D Y L K
Honey Bee Apis mellifera XP_001121207 890 100774 L364 R I P D L Q V L A K K L A R K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays Q9XGC9 942 105052 G371 E D P E L R Q G L R Q Q L K R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O24617 937 105485 D369 E E A G L R Q D L R Q H L K R
Baker's Yeast Sacchar. cerevisiae P25847 964 108866 M387 D Q I E L R Q M L T S E Y L P
Red Bread Mold Neurospora crassa O13396 937 105050 S364 N D T E L R Q S M Q E E H L R
Conservation
Percent
Protein Identity: 100 N.A. N.A. 96.1 N.A. 92.4 91.4 N.A. N.A. 76.3 N.A. 71.9 N.A. 42.8 46.9 N.A. N.A.
Protein Similarity: 100 N.A. N.A. 98.3 N.A. 96.3 96.2 N.A. N.A. 87.2 N.A. 88.2 N.A. 63.1 66.6 N.A. N.A.
P-Site Identity: 100 N.A. N.A. 93.3 N.A. 86.6 80 N.A. N.A. 80 N.A. 73.3 N.A. 33.3 6.6 N.A. N.A.
P-Site Similarity: 100 N.A. N.A. 100 N.A. 100 93.3 N.A. N.A. 80 N.A. 93.3 N.A. 53.3 40 N.A. N.A.
Percent
Protein Identity: N.A. 42.1 N.A. 41.8 40.3 47.6
Protein Similarity: N.A. 62.9 N.A. 62.5 62 65.6
P-Site Identity: N.A. 60 N.A. 53.3 40 60
P-Site Similarity: N.A. 73.3 N.A. 73.3 53.3 80
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 25 0 0 0 0 9 9 0 0 0 9 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % C
% Asp: 9 67 0 17 0 0 0 9 0 0 0 59 0 0 0 % D
% Glu: 67 9 0 75 0 0 9 0 0 0 59 17 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 9 0 0 0 17 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 9 9 0 0 % H
% Ile: 0 9 9 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 9 0 0 9 9 0 0 17 17 % K
% Leu: 0 0 0 0 92 0 0 9 75 0 9 9 67 75 0 % L
% Met: 0 0 0 0 0 9 0 9 9 0 0 0 0 0 0 % M
% Asn: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 25 0 0 0 0 0 0 0 0 0 0 0 9 % P
% Gln: 0 9 0 0 0 9 67 0 0 59 17 9 0 0 0 % Q
% Arg: 9 0 0 0 0 84 9 0 0 17 0 0 0 9 75 % R
% Ser: 0 9 25 0 0 0 0 34 0 9 9 0 0 0 0 % S
% Thr: 0 0 17 0 9 0 0 17 0 9 0 0 0 0 0 % T
% Val: 9 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 17 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _