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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GRK6
All Species:
39.7
Human Site:
T494
Identified Species:
79.39
UniProt:
P43250
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43250
NP_001004105.1
576
65991
T494
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
Chimpanzee
Pan troglodytes
XP_527138
582
66476
T487
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
Rhesus Macaque
Macaca mulatta
XP_001090350
576
66059
T494
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
Dog
Lupus familis
XP_544045
601
68781
T505
K
G
V
N
L
D
H
T
D
D
D
F
Y
S
K
Cat
Felis silvestris
Mouse
Mus musculus
O70293
576
65960
T494
K
G
V
D
L
E
P
T
D
Q
D
F
Y
Q
K
Rat
Rattus norvegicus
P97711
576
65944
T494
K
G
V
D
L
E
P
T
D
Q
D
F
Y
Q
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514876
728
82806
T483
K
G
V
E
L
E
S
T
D
N
D
F
Y
Q
K
Chicken
Gallus gallus
XP_414676
689
78536
T608
K
G
V
E
L
E
P
T
D
N
D
F
Y
Q
K
Frog
Xenopus laevis
NP_001087513
575
66421
T494
K
G
I
D
L
E
Q
T
D
N
D
F
Y
H
K
Zebra Danio
Brachydanio rerio
XP_689783
575
66134
K494
K
G
V
E
L
E
P
K
D
D
S
F
Y
S
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P32866
714
80668
S622
K
G
V
N
I
D
E
S
D
T
N
F
Y
T
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09537
642
73759
T525
K
G
V
R
L
D
A
T
D
T
Q
F
Y
G
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.3
99.3
65
N.A.
96.6
96.6
N.A.
65.9
73
82.1
84.1
N.A.
50.4
N.A.
53.8
N.A.
Protein Similarity:
100
95.5
99.8
78
N.A.
98.2
98
N.A.
69.9
77
89.7
90.6
N.A.
62.4
N.A.
66.9
N.A.
P-Site Identity:
100
100
100
66.6
N.A.
93.3
93.3
N.A.
86.6
93.3
66.6
73.3
N.A.
46.6
N.A.
60
N.A.
P-Site Similarity:
100
100
100
73.3
N.A.
100
100
N.A.
86.6
93.3
80
73.3
N.A.
73.3
N.A.
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
25
0
25
0
0
100
17
75
0
0
0
0
% D
% Glu:
0
0
0
50
0
75
9
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
100
0
0
0
% F
% Gly:
0
100
0
0
0
0
0
0
0
0
0
0
0
9
0
% G
% His:
0
0
0
0
0
0
9
0
0
0
0
0
0
9
0
% H
% Ile:
0
0
9
0
9
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
100
0
0
0
0
0
0
9
0
0
0
0
0
0
100
% K
% Leu:
0
0
0
0
92
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
17
0
0
0
0
0
25
9
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
59
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
9
0
0
42
9
0
0
59
0
% Q
% Arg:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
9
9
0
0
9
0
0
17
0
% S
% Thr:
0
0
0
0
0
0
0
84
0
17
0
0
0
9
0
% T
% Val:
0
0
92
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
100
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _