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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SYK
All Species:
0.61
Human Site:
S306
Identified Species:
1.33
UniProt:
P43405
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43405
NP_001128524.1
635
72066
S306
P
K
P
G
H
R
K
S
S
P
A
Q
G
N
R
Chimpanzee
Pan troglodytes
XP_520123
544
61880
V256
A
L
P
M
D
T
E
V
Y
E
S
P
Y
A
D
Rhesus Macaque
Macaca mulatta
XP_001100834
635
72070
P306
P
K
P
G
H
R
K
P
S
P
A
Q
G
N
R
Dog
Lupus familis
XP_850411
644
73172
K305
G
G
I
I
S
R
I
K
S
Y
T
F
P
K
P
Cat
Felis silvestris
Mouse
Mus musculus
P48025
629
71358
G305
K
K
P
A
P
P
Q
G
S
R
P
E
S
T
V
Rat
Rattus norvegicus
Q64725
629
71510
G305
K
K
P
P
P
P
Q
G
S
R
P
E
S
T
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026601
613
69811
R305
P
Y
V
L
Q
R
A
R
G
L
I
G
A
E
K
Frog
Xenopus laevis
NP_001083616
609
69575
E301
R
S
S
T
A
I
N
E
Y
A
R
R
P
N
V
Zebra Danio
Brachydanio rerio
NP_998008
586
67629
T298
D
S
A
M
P
M
D
T
Q
V
Y
E
S
P
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24145
939
104255
L450
Q
H
P
H
V
P
A
L
T
I
T
K
K
K
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001180232
837
93621
E489
E
P
P
L
S
P
I
E
R
E
G
S
I
P
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.5
99
91.1
N.A.
92.1
91
N.A.
N.A.
77.4
67.7
65.9
N.A.
25.5
N.A.
N.A.
26.5
Protein Similarity:
100
85.6
99.5
94.4
N.A.
94.4
93.6
N.A.
N.A.
87.4
79
77.4
N.A.
39.9
N.A.
N.A.
40.7
P-Site Identity:
100
6.6
93.3
13.3
N.A.
20
20
N.A.
N.A.
13.3
6.6
0
N.A.
6.6
N.A.
N.A.
6.6
P-Site Similarity:
100
20
93.3
13.3
N.A.
33.3
33.3
N.A.
N.A.
20
13.3
13.3
N.A.
26.6
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
10
10
0
19
0
0
10
19
0
10
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
0
10
0
10
0
0
0
0
0
0
0
10
% D
% Glu:
10
0
0
0
0
0
10
19
0
19
0
28
0
10
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% F
% Gly:
10
10
0
19
0
0
0
19
10
0
10
10
19
0
0
% G
% His:
0
10
0
10
19
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
10
0
10
19
0
0
10
10
0
10
0
0
% I
% Lys:
19
37
0
0
0
0
19
10
0
0
0
10
10
19
10
% K
% Leu:
0
10
0
19
0
0
0
10
0
10
0
0
0
0
0
% L
% Met:
0
0
0
19
0
10
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
0
0
0
0
10
0
0
0
0
0
0
28
0
% N
% Pro:
28
10
64
10
28
37
0
10
0
19
19
10
19
19
10
% P
% Gln:
10
0
0
0
10
0
19
0
10
0
0
19
0
0
10
% Q
% Arg:
10
0
0
0
0
37
0
10
10
19
10
10
0
0
19
% R
% Ser:
0
19
10
0
19
0
0
10
46
0
10
10
28
0
0
% S
% Thr:
0
0
0
10
0
10
0
10
10
0
19
0
0
19
0
% T
% Val:
0
0
10
0
10
0
0
10
0
10
0
0
0
0
28
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
0
0
0
0
0
19
10
10
0
10
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _