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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SYK All Species: 21.21
Human Site: T345 Identified Species: 46.67
UniProt: P43405 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P43405 NP_001128524.1 635 72066 T345 R E A L P M D T E V Y E S P Y
Chimpanzee Pan troglodytes XP_520123 544 61880 S288 L E D K E L G S G N F G T V K
Rhesus Macaque Macaca mulatta XP_001100834 635 72070 T345 R E A L P M D T E V Y E S P Y
Dog Lupus familis XP_850411 644 73172 T354 R E A L P M D T E V Y E S P Y
Cat Felis silvestris
Mouse Mus musculus P48025 629 71358 T339 R E A L P M D T E V Y E S P Y
Rat Rattus norvegicus Q64725 629 71510 T339 R E A L P M D T E V Y E S P Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001026601 613 69811 V341 D E I K P K N V T L D R K L L
Frog Xenopus laevis NP_001083616 609 69575 G337 D E F R P K D G Q I A P E Q L
Zebra Danio Brachydanio rerio NP_998008 586 67629 S330 L E D G E L G S G N F G T V L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24145 939 104255 C636 A S Y L H R K C S G T P S T P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001180232 837 93621 K542 R Q R K E L Q K A I H E A P G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 85.5 99 91.1 N.A. 92.1 91 N.A. N.A. 77.4 67.7 65.9 N.A. 25.5 N.A. N.A. 26.5
Protein Similarity: 100 85.6 99.5 94.4 N.A. 94.4 93.6 N.A. N.A. 87.4 79 77.4 N.A. 39.9 N.A. N.A. 40.7
P-Site Identity: 100 6.6 100 100 N.A. 100 100 N.A. N.A. 13.3 20 6.6 N.A. 13.3 N.A. N.A. 20
P-Site Similarity: 100 33.3 100 100 N.A. 100 100 N.A. N.A. 26.6 33.3 33.3 N.A. 13.3 N.A. N.A. 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 46 0 0 0 0 0 10 0 10 0 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % C
% Asp: 19 0 19 0 0 0 55 0 0 0 10 0 0 0 0 % D
% Glu: 0 82 0 0 28 0 0 0 46 0 0 55 10 0 0 % E
% Phe: 0 0 10 0 0 0 0 0 0 0 19 0 0 0 0 % F
% Gly: 0 0 0 10 0 0 19 10 19 10 0 19 0 0 10 % G
% His: 0 0 0 0 10 0 0 0 0 0 10 0 0 0 0 % H
% Ile: 0 0 10 0 0 0 0 0 0 19 0 0 0 0 0 % I
% Lys: 0 0 0 28 0 19 10 10 0 0 0 0 10 0 10 % K
% Leu: 19 0 0 55 0 28 0 0 0 10 0 0 0 10 28 % L
% Met: 0 0 0 0 0 46 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 10 0 0 19 0 0 0 0 0 % N
% Pro: 0 0 0 0 64 0 0 0 0 0 0 19 0 55 10 % P
% Gln: 0 10 0 0 0 0 10 0 10 0 0 0 0 10 0 % Q
% Arg: 55 0 10 10 0 10 0 0 0 0 0 10 0 0 0 % R
% Ser: 0 10 0 0 0 0 0 19 10 0 0 0 55 0 0 % S
% Thr: 0 0 0 0 0 0 0 46 10 0 10 0 19 10 0 % T
% Val: 0 0 0 0 0 0 0 10 0 46 0 0 0 19 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 0 0 0 0 0 0 46 0 0 0 46 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _