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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SYK
All Species:
29.39
Human Site:
Y244
Identified Species:
64.67
UniProt:
P43405
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43405
NP_001128524.1
635
72066
Y244
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
G
L
Chimpanzee
Pan troglodytes
XP_520123
544
61880
S194
G
S
H
P
A
T
W
S
A
G
G
I
I
S
R
Rhesus Macaque
Macaca mulatta
XP_001100834
635
72070
Y244
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
G
L
Dog
Lupus familis
XP_850411
644
73172
Y243
L
W
Q
L
V
E
H
Y
S
Y
K
P
D
G
L
Cat
Felis silvestris
Mouse
Mus musculus
P48025
629
71358
Y243
L
W
Q
L
V
E
H
Y
S
Y
K
P
D
G
L
Rat
Rattus norvegicus
Q64725
629
71510
Y243
L
W
Q
L
V
E
H
Y
S
Y
K
P
D
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026601
613
69811
Y243
L
W
Q
L
V
E
H
Y
S
Y
K
P
D
G
L
Frog
Xenopus laevis
NP_001083616
609
69575
Y239
L
W
Q
L
V
E
H
Y
S
Y
K
P
D
G
L
Zebra Danio
Brachydanio rerio
NP_998008
586
67629
L236
D
G
K
K
F
D
T
L
W
Q
L
V
E
H
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24145
939
104255
F388
V
E
H
L
I
A
H
F
M
R
F
S
Y
G
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001180232
837
93621
Y427
L
E
Q
L
I
D
H
Y
S
R
Y
D
D
G
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.5
99
91.1
N.A.
92.1
91
N.A.
N.A.
77.4
67.7
65.9
N.A.
25.5
N.A.
N.A.
26.5
Protein Similarity:
100
85.6
99.5
94.4
N.A.
94.4
93.6
N.A.
N.A.
87.4
79
77.4
N.A.
39.9
N.A.
N.A.
40.7
P-Site Identity:
100
0
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
93.3
93.3
0
N.A.
26.6
N.A.
N.A.
60
P-Site Similarity:
100
6.6
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
93.3
93.3
20
N.A.
53.3
N.A.
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
10
0
0
10
0
0
19
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
0
0
19
0
0
0
0
0
10
73
0
0
% D
% Glu:
0
19
0
0
0
64
0
0
0
0
0
0
10
0
0
% E
% Phe:
0
0
0
0
10
0
0
10
0
0
10
0
0
0
0
% F
% Gly:
10
10
0
0
0
0
0
0
0
10
10
0
0
82
0
% G
% His:
0
0
19
0
0
0
82
0
0
0
0
0
0
10
0
% H
% Ile:
0
0
0
0
19
0
0
0
0
0
0
10
10
0
0
% I
% Lys:
0
0
10
10
0
0
0
0
0
0
64
0
0
0
0
% K
% Leu:
73
0
0
82
0
0
0
10
0
0
10
0
0
0
82
% L
% Met:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
10
0
0
0
0
0
0
0
46
0
0
0
% P
% Gln:
0
0
73
0
0
0
0
0
0
10
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
19
0
0
0
0
10
% R
% Ser:
0
10
0
0
0
0
0
10
73
0
0
10
0
10
0
% S
% Thr:
0
0
0
0
0
10
10
0
0
0
0
0
0
0
0
% T
% Val:
10
0
0
0
64
0
0
0
0
0
0
10
0
0
0
% V
% Trp:
0
64
0
0
0
0
10
0
10
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
73
0
64
10
0
10
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _