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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHRNA4
All Species:
18.48
Human Site:
S488
Identified Species:
45.19
UniProt:
P43681
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43681
NP_000735.1
627
69957
S488
G
V
R
C
R
S
R
S
I
Q
Y
C
V
P
R
Chimpanzee
Pan troglodytes
Q5IS77
627
69934
S488
G
I
R
C
R
S
R
S
I
Q
Y
C
V
P
R
Rhesus Macaque
Macaca mulatta
XP_001114265
659
73255
S520
G
V
R
C
R
S
R
S
I
Q
Y
C
V
P
R
Dog
Lupus familis
XP_543097
681
74998
Q547
R
C
R
S
R
S
I
Q
Y
G
G
P
Q
D
A
Cat
Felis silvestris
Mouse
Mus musculus
O70174
629
70286
S491
S
I
R
C
R
S
R
S
I
Q
Y
C
V
S
Q
Rat
Rattus norvegicus
P09483
630
70174
S491
E
D
G
I
R
C
R
S
R
S
I
Q
Y
C
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506577
624
70583
S479
G
I
R
C
R
S
R
S
I
Q
Y
F
Y
L
Q
Chicken
Gallus gallus
P09482
622
70820
S483
E
G
S
I
R
C
R
S
R
S
I
Q
Y
C
Y
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001041528
627
71089
E483
Q
D
G
A
K
S
T
E
C
D
F
Q
G
H
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P09478
567
64001
N446
L
F
S
P
S
G
L
N
G
D
I
S
P
G
C
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.4
89.9
79.1
N.A.
84.7
83.8
N.A.
74.8
74.3
N.A.
62.2
N.A.
37.3
N.A.
N.A.
N.A.
Protein Similarity:
100
98.8
91
82.2
N.A.
89
87.4
N.A.
81.8
81.9
N.A.
70.6
N.A.
52.7
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
100
20
N.A.
73.3
20
N.A.
66.6
20
N.A.
6.6
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
20
N.A.
86.6
20
N.A.
80
20
N.A.
20
N.A.
6.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
10
% A
% Cys:
0
10
0
50
0
20
0
0
10
0
0
40
0
20
10
% C
% Asp:
0
20
0
0
0
0
0
0
0
20
0
0
0
10
0
% D
% Glu:
20
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% E
% Phe:
0
10
0
0
0
0
0
0
0
0
10
10
0
0
0
% F
% Gly:
40
10
20
0
0
10
0
0
10
10
10
0
10
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% H
% Ile:
0
30
0
20
0
0
10
0
50
0
30
0
0
0
0
% I
% Lys:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
10
0
0
0
0
0
10
0
0
0
0
0
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
10
0
0
0
0
0
0
0
10
10
30
0
% P
% Gln:
10
0
0
0
0
0
0
10
0
50
0
30
10
0
20
% Q
% Arg:
10
0
60
0
80
0
70
0
20
0
0
0
0
0
30
% R
% Ser:
10
0
20
10
10
70
0
70
0
20
0
10
0
10
10
% S
% Thr:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% T
% Val:
0
20
0
0
0
0
0
0
0
0
0
0
40
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
10
0
50
0
30
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _