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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PSMC4 All Species: 67.88
Human Site: S129 Identified Species: 93.33
UniProt: P43686 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P43686 NP_006494.1 418 47366 S129 E L L K P N A S V A L H K H S
Chimpanzee Pan troglodytes XP_001141067 422 47807 S129 E L L K P N A S V A L H K H S
Rhesus Macaque Macaca mulatta XP_001090437 422 47818 S129 E L L K P N A S V A L H K H S
Dog Lupus familis XP_867041 419 47479 S129 E L L K P N A S V A L H K H S
Cat Felis silvestris
Mouse Mus musculus P54775 418 47263 S129 E L L K P N A S V A L H K H S
Rat Rattus norvegicus Q63570 418 47390 S129 E L L K P N A S V A L H K H S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518401 484 54060 S231 E L L K P N A S V A L H K H S
Chicken Gallus gallus Q90732 440 49185 S149 D L L E P G C S V L L N H K V
Frog Xenopus laevis NP_001083300 420 47373 S131 E L L K P N A S V A L H K H S
Zebra Danio Brachydanio rerio NP_956044 418 47242 S129 E L L K P N A S V A L H K H S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P48601 439 49305 S148 D Q L E P G C S V L L N H K V
Honey Bee Apis mellifera XP_393513 415 47021 S126 E L L K P S A S V A L H K H S
Nematode Worm Caenorhab. elegans P46502 414 46340 S125 E L L K P G C S V A L H K Y S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002322593 412 46473 S123 E L L K P S A S V A L H R H S
Maize Zea mays NP_001150600 420 46705 S131 E L L K P S A S V A L H R H S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SEI4 408 45733 S119 E L L K P S A S V A L H R H S
Baker's Yeast Sacchar. cerevisiae P33298 428 47951 S136 E L L K P S M S V A L H R H S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 99 99.5 N.A. 97.8 99.7 N.A. 73.9 45.2 95.9 96.6 N.A. 46 85.4 76.7 N.A.
Protein Similarity: 100 99 99 99.7 N.A. 98.3 99.7 N.A. 77.2 68.1 97.6 98.5 N.A. 70.1 92.5 85.4 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 100 40 100 100 N.A. 33.3 93.3 80 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 60 100 100 N.A. 53.3 100 86.6 N.A.
Percent
Protein Identity: 77.7 77.1 N.A. 77 67.2 N.A.
Protein Similarity: 87.3 85.7 N.A. 85.8 81.7 N.A.
P-Site Identity: 86.6 86.6 N.A. 86.6 80 N.A.
P-Site Similarity: 100 100 N.A. 100 93.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 77 0 0 89 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 18 0 0 0 0 0 0 0 0 % C
% Asp: 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 89 0 0 12 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 18 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 89 12 83 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 89 0 0 0 0 0 0 0 0 65 12 0 % K
% Leu: 0 95 100 0 0 0 0 0 0 12 100 0 0 0 0 % L
% Met: 0 0 0 0 0 0 6 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 53 0 0 0 0 0 12 0 0 0 % N
% Pro: 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 24 0 0 % R
% Ser: 0 0 0 0 0 30 0 100 0 0 0 0 0 0 89 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 100 0 0 0 0 0 12 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 6 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _