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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PSMC4 All Species: 29.7
Human Site: S21 Identified Species: 40.83
UniProt: P43686 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P43686 NP_006494.1 418 47366 S21 E I P A L S V S R P Q T G L S
Chimpanzee Pan troglodytes XP_001141067 422 47807 S21 E I P A L S V S R P Q T G L S
Rhesus Macaque Macaca mulatta XP_001090437 422 47818 S21 E I P A L S V S R P Q T G L S
Dog Lupus familis XP_867041 419 47479 S21 E I P A L S V S R P Q T G L S
Cat Felis silvestris
Mouse Mus musculus P54775 418 47263 S21 E I P A L S V S R P Q T G L S
Rat Rattus norvegicus Q63570 418 47390 S21 E I P A L S V S R P Q T G L S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518401 484 54060 A123 R K R R P R S A P R P G A M E
Chicken Gallus gallus Q90732 440 49185 R32 Y E P P V P T R V G K K K K K
Frog Xenopus laevis NP_001083300 420 47373 S23 E A P S L V S S R P L T A L S
Zebra Danio Brachydanio rerio NP_956044 418 47242 S21 D V P A L L N S R P Q T G L S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P48601 439 49305 R31 Y E P P I P T R V G K K K R R
Honey Bee Apis mellifera XP_393513 415 47021 C18 K D V G E M E C K P V I G H Y
Nematode Worm Caenorhab. elegans P46502 414 46340 N17 G I A P L Q E N T S L R P P P
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002322593 412 46473 E15 P K P A P A T E P R S D L V L
Maize Zea mays NP_001150600 420 46705 P23 M A P P P S Y P A S S T I S A
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SEI4 408 45733 L11 A A V A S M V L D P K A S P A
Baker's Yeast Sacchar. cerevisiae P33298 428 47951 A28 K S Y A S L L A Q L N G T V N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 99 99.5 N.A. 97.8 99.7 N.A. 73.9 45.2 95.9 96.6 N.A. 46 85.4 76.7 N.A.
Protein Similarity: 100 99 99 99.7 N.A. 98.3 99.7 N.A. 77.2 68.1 97.6 98.5 N.A. 70.1 92.5 85.4 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 0 6.6 60 73.3 N.A. 6.6 13.3 13.3 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 13.3 20 66.6 86.6 N.A. 20 26.6 20 N.A.
Percent
Protein Identity: 77.7 77.1 N.A. 77 67.2 N.A.
Protein Similarity: 87.3 85.7 N.A. 85.8 81.7 N.A.
P-Site Identity: 13.3 20 N.A. 20 6.6 N.A.
P-Site Similarity: 26.6 26.6 N.A. 33.3 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 18 6 59 0 6 0 12 6 0 0 6 12 0 12 % A
% Cys: 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 % C
% Asp: 6 6 0 0 0 0 0 0 6 0 0 6 0 0 0 % D
% Glu: 42 12 0 0 6 0 12 6 0 0 0 0 0 0 6 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 6 0 0 6 0 0 0 0 0 12 0 12 48 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 6 0 % H
% Ile: 0 42 0 0 6 0 0 0 0 0 0 6 6 0 0 % I
% Lys: 12 12 0 0 0 0 0 0 6 0 18 12 12 6 6 % K
% Leu: 0 0 0 0 53 12 6 6 0 6 12 0 6 48 6 % L
% Met: 6 0 0 0 0 12 0 0 0 0 0 0 0 6 0 % M
% Asn: 0 0 0 0 0 0 6 6 0 0 6 0 0 0 6 % N
% Pro: 6 0 71 24 18 12 0 6 12 59 6 0 6 12 6 % P
% Gln: 0 0 0 0 0 6 0 0 6 0 42 0 0 0 0 % Q
% Arg: 6 0 6 6 0 6 0 12 48 12 0 6 0 6 6 % R
% Ser: 0 6 0 6 12 42 12 48 0 12 12 0 6 6 48 % S
% Thr: 0 0 0 0 0 0 18 0 6 0 0 53 6 0 0 % T
% Val: 0 6 12 0 6 6 42 0 12 0 6 0 0 12 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 12 0 6 0 0 0 6 0 0 0 0 0 0 0 6 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _