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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PSMC4 All Species: 30.91
Human Site: T25 Identified Species: 42.5
UniProt: P43686 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P43686 NP_006494.1 418 47366 T25 L S V S R P Q T G L S F L G P
Chimpanzee Pan troglodytes XP_001141067 422 47807 T25 L S V S R P Q T G L S F L G P
Rhesus Macaque Macaca mulatta XP_001090437 422 47818 T25 L S V S R P Q T G L S F L G P
Dog Lupus familis XP_867041 419 47479 T25 L S V S R P Q T G L S F L G P
Cat Felis silvestris
Mouse Mus musculus P54775 418 47263 T25 L S V S R P Q T G L S F L G P
Rat Rattus norvegicus Q63570 418 47390 T25 L S V S R P Q T G L S F L G P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518401 484 54060 G127 P R S A P R P G A M E E I G I
Chicken Gallus gallus Q90732 440 49185 K36 V P T R V G K K K K K T K G P
Frog Xenopus laevis NP_001083300 420 47373 T27 L V S S R P L T A L S F L G P
Zebra Danio Brachydanio rerio NP_956044 418 47242 T25 L L N S R P Q T G L S F L A P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P48601 439 49305 K35 I P T R V G K K K R R A K G P
Honey Bee Apis mellifera XP_393513 415 47021 I22 E M E C K P V I G H Y T G A G
Nematode Worm Caenorhab. elegans P46502 414 46340 R21 L Q E N T S L R P P P L P A T
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002322593 412 46473 D19 P A T E P R S D L V L D P S T
Maize Zea mays NP_001150600 420 46705 T27 P S Y P A S S T I S A S V A A
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SEI4 408 45733 A15 S M V L D P K A S P A L M D L
Baker's Yeast Sacchar. cerevisiae P33298 428 47951 G32 S L L A Q L N G T V N N N S A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 99 99.5 N.A. 97.8 99.7 N.A. 73.9 45.2 95.9 96.6 N.A. 46 85.4 76.7 N.A.
Protein Similarity: 100 99 99 99.7 N.A. 98.3 99.7 N.A. 77.2 68.1 97.6 98.5 N.A. 70.1 92.5 85.4 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 6.6 13.3 73.3 80 N.A. 13.3 13.3 6.6 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 26.6 26.6 73.3 80 N.A. 26.6 20 13.3 N.A.
Percent
Protein Identity: 77.7 77.1 N.A. 77 67.2 N.A.
Protein Similarity: 87.3 85.7 N.A. 85.8 81.7 N.A.
P-Site Identity: 0 13.3 N.A. 13.3 0 N.A.
P-Site Similarity: 13.3 26.6 N.A. 33.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 6 0 12 6 0 0 6 12 0 12 6 0 24 12 % A
% Cys: 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 6 0 0 6 0 0 0 6 0 6 0 % D
% Glu: 6 0 12 6 0 0 0 0 0 0 6 6 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 48 0 0 0 % F
% Gly: 0 0 0 0 0 12 0 12 48 0 0 0 6 59 6 % G
% His: 0 0 0 0 0 0 0 0 0 6 0 0 0 0 0 % H
% Ile: 6 0 0 0 0 0 0 6 6 0 0 0 6 0 6 % I
% Lys: 0 0 0 0 6 0 18 12 12 6 6 0 12 0 0 % K
% Leu: 53 12 6 6 0 6 12 0 6 48 6 12 48 0 6 % L
% Met: 0 12 0 0 0 0 0 0 0 6 0 0 6 0 0 % M
% Asn: 0 0 6 6 0 0 6 0 0 0 6 6 6 0 0 % N
% Pro: 18 12 0 6 12 59 6 0 6 12 6 0 12 0 59 % P
% Gln: 0 6 0 0 6 0 42 0 0 0 0 0 0 0 0 % Q
% Arg: 0 6 0 12 48 12 0 6 0 6 6 0 0 0 0 % R
% Ser: 12 42 12 48 0 12 12 0 6 6 48 6 0 12 0 % S
% Thr: 0 0 18 0 6 0 0 53 6 0 0 12 0 0 12 % T
% Val: 6 6 42 0 12 0 6 0 0 12 0 0 6 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 6 0 0 0 0 0 0 0 6 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _