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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MMP13
All Species:
31.21
Human Site:
S227
Identified Species:
76.3
UniProt:
P45452
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P45452
NP_002418.1
471
53820
S227
A
A
H
E
F
G
H
S
L
G
L
D
H
S
K
Chimpanzee
Pan troglodytes
XP_001154361
471
53815
S227
A
A
H
E
F
G
H
S
L
G
L
D
H
S
K
Rhesus Macaque
Macaca mulatta
XP_001098996
471
53835
S227
A
A
H
E
F
G
H
S
L
G
L
D
H
S
K
Dog
Lupus familis
XP_536598
470
53609
S226
A
A
H
E
F
G
H
S
L
G
L
D
H
S
K
Cat
Felis silvestris
Mouse
Mus musculus
P33435
472
54164
S228
A
A
H
E
L
G
H
S
L
G
L
D
H
S
K
Rat
Rattus norvegicus
P23097
466
53357
S222
A
A
H
E
L
G
H
S
L
G
L
D
H
S
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509903
471
53417
S227
A
A
H
E
F
G
H
S
L
G
L
D
H
S
R
Chicken
Gallus gallus
XP_001235210
471
54415
S227
A
A
H
E
F
G
H
S
L
G
L
E
H
S
R
Frog
Xenopus laevis
Q10835
469
53622
A225
A
A
H
E
F
G
H
A
L
G
L
D
H
S
R
Zebra Danio
Brachydanio rerio
XP_001345507
461
52634
H223
G
H
A
L
G
M
A
H
S
S
D
P
G
S
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
99.1
92.3
N.A.
86.4
85.7
N.A.
73.6
70.4
66.4
55.8
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
99.5
95.5
N.A.
92.3
91.9
N.A.
85.3
84
80.8
69.8
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
93.3
86.6
86.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
100
100
100
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
90
90
10
0
0
0
10
10
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
10
80
0
0
0
% D
% Glu:
0
0
0
90
0
0
0
0
0
0
0
10
0
0
0
% E
% Phe:
0
0
0
0
70
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
10
0
0
0
10
90
0
0
0
90
0
0
10
0
0
% G
% His:
0
10
90
0
0
0
90
10
0
0
0
0
90
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
60
% K
% Leu:
0
0
0
10
20
0
0
0
90
0
90
0
0
0
10
% L
% Met:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
30
% R
% Ser:
0
0
0
0
0
0
0
80
10
10
0
0
0
100
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _