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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MMP13 All Species: 33.94
Human Site: S289 Identified Species: 82.96
UniProt: P45452 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P45452 NP_002418.1 471 53820 S289 D K C D P S L S L D A I T S L
Chimpanzee Pan troglodytes XP_001154361 471 53815 S289 D K C D P S L S L D A I T S L
Rhesus Macaque Macaca mulatta XP_001098996 471 53835 S289 D K C D P S L S L D A I T S L
Dog Lupus familis XP_536598 470 53609 S288 D K C D P S L S L D A I T S L
Cat Felis silvestris
Mouse Mus musculus P33435 472 54164 S290 E K C D P A L S L D A I T S L
Rat Rattus norvegicus P23097 466 53357 S284 E K C D P A L S L D A I T S L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509903 471 53417 S289 E K C D A N L S L D A I T E L
Chicken Gallus gallus XP_001235210 471 54415 S289 E K C A A D L S I D A I T K L
Frog Xenopus laevis Q10835 469 53622 S287 E K C D P D L S I D A I T E L
Zebra Danio Brachydanio rerio XP_001345507 461 52634 E285 L S F D A I T E L R G E T I I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 99.1 92.3 N.A. 86.4 85.7 N.A. 73.6 70.4 66.4 55.8 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.5 99.5 95.5 N.A. 92.3 91.9 N.A. 85.3 84 80.8 69.8 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 86.6 86.6 N.A. 73.3 60 73.3 20 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 86.6 73.3 86.6 26.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 10 30 20 0 0 0 0 90 0 0 0 0 % A
% Cys: 0 0 90 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 40 0 0 90 0 20 0 0 0 90 0 0 0 0 0 % D
% Glu: 50 0 0 0 0 0 0 10 0 0 0 10 0 20 0 % E
% Phe: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 10 0 0 20 0 0 90 0 10 10 % I
% Lys: 0 90 0 0 0 0 0 0 0 0 0 0 0 10 0 % K
% Leu: 10 0 0 0 0 0 90 0 80 0 0 0 0 0 90 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 70 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % R
% Ser: 0 10 0 0 0 40 0 90 0 0 0 0 0 60 0 % S
% Thr: 0 0 0 0 0 0 10 0 0 0 0 0 100 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _