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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K4
All Species:
21.82
Human Site:
S115
Identified Species:
34.29
UniProt:
P45985
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P45985
NP_003001.1
399
44288
S115
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
C121
E
L
Q
V
L
H
E
C
N
S
P
Y
I
V
G
Rhesus Macaque
Macaca mulatta
XP_001114292
410
45566
S126
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
Dog
Lupus familis
XP_546627
413
46697
S129
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
Cat
Felis silvestris
Mouse
Mus musculus
P47809
397
44095
S113
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
Rat
Rattus norvegicus
Q4KSH7
419
47517
Q133
M
G
S
G
T
C
G
Q
V
W
K
M
R
F
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90891
398
44059
C123
E
L
Q
V
L
H
E
C
N
S
P
Y
I
V
G
Frog
Xenopus laevis
Q07192
446
50082
S162
I
G
R
G
A
Y
G
S
V
N
K
M
S
H
T
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
A90
I
G
E
L
G
R
G
A
Y
G
V
V
D
K
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477353
424
47515
A135
I
G
R
G
A
F
G
A
V
N
K
M
T
F
K
Honey Bee
Apis mellifera
XP_394054
436
49631
T150
I
G
R
G
G
F
G
T
V
N
K
M
I
H
R
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
I92
H
K
E
T
G
K
L
I
A
V
K
R
I
R
C
Sea Urchin
Strong. purpuratus
XP_794490
382
43817
K111
S
V
N
K
M
W
H
K
Q
S
Q
S
I
M
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
Q85
K
G
S
G
G
V
V
Q
L
V
R
H
K
W
V
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
N373
L
G
H
G
N
Y
G
N
V
S
K
V
L
H
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.3
97.3
89.3
N.A.
97.9
41.7
N.A.
N.A.
36.5
77.3
48.3
N.A.
54
55.9
44.6
55.8
Protein Similarity:
100
53.6
97.3
90.5
N.A.
98.2
57.2
N.A.
N.A.
53.8
80.9
64.4
N.A.
65.8
68.8
61.6
71.1
P-Site Identity:
100
0
100
100
N.A.
100
40
N.A.
N.A.
0
86.6
20
N.A.
73.3
66.6
6.6
0
P-Site Similarity:
100
26.6
100
100
N.A.
100
53.3
N.A.
N.A.
26.6
86.6
33.3
N.A.
86.6
93.3
13.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
31
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.3
38.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
53.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
86.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
40
0
0
14
7
0
0
0
0
0
7
% A
% Cys:
0
0
0
0
0
7
0
14
0
0
0
0
0
0
7
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% D
% Glu:
14
0
14
0
0
0
14
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
14
0
0
0
0
0
0
0
14
0
% F
% Gly:
0
74
0
67
27
0
67
0
0
7
0
0
0
0
14
% G
% His:
7
0
7
0
0
14
7
0
0
0
0
7
0
47
0
% H
% Ile:
54
0
0
0
0
0
0
7
0
0
0
0
34
0
0
% I
% Lys:
7
7
0
7
0
7
0
7
0
0
67
0
7
7
40
% K
% Leu:
7
14
0
7
14
0
7
0
7
0
0
0
7
0
0
% L
% Met:
7
0
0
0
7
0
0
0
0
0
0
54
0
7
7
% M
% Asn:
0
0
7
0
7
0
0
7
14
47
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
14
0
0
0
0
% P
% Gln:
0
0
14
0
0
0
0
14
7
0
7
0
0
0
0
% Q
% Arg:
0
0
47
0
0
7
0
0
0
0
7
7
7
7
14
% R
% Ser:
7
0
14
0
0
0
0
34
0
27
0
7
7
0
0
% S
% Thr:
0
0
0
7
7
0
0
7
0
0
0
0
7
0
7
% T
% Val:
0
7
0
14
0
7
7
0
60
14
7
14
27
14
7
% V
% Trp:
0
0
0
0
0
7
0
0
0
7
0
0
0
7
0
% W
% Tyr:
0
0
0
0
0
40
0
0
7
0
0
14
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _