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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K4
All Species:
18.79
Human Site:
S240
Identified Species:
29.52
UniProt:
P45985
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P45985
NP_003001.1
399
44288
S240
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
R234
R
S
Y
M
S
P
E
R
F
Q
G
T
H
Y
S
Rhesus Macaque
Macaca mulatta
XP_001114292
410
45566
S251
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
Dog
Lupus familis
XP_546627
413
46697
S254
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
Cat
Felis silvestris
Mouse
Mus musculus
P47809
397
44095
S238
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
Rat
Rattus norvegicus
Q4KSH7
419
47517
R254
S
N
I
L
L
D
E
R
G
Q
I
K
L
C
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90891
398
44059
T240
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
Frog
Xenopus laevis
Q07192
446
50082
N287
S
N
I
L
L
D
T
N
G
N
I
K
L
C
D
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
I203
L
H
S
N
L
S
V
I
H
R
D
V
K
P
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477353
424
47515
R260
S
N
I
L
L
H
R
R
G
D
I
K
L
C
D
Honey Bee
Apis mellifera
XP_394054
436
49631
H275
S
N
I
L
L
D
R
H
G
N
I
K
L
C
D
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
T205
S
N
I
L
V
D
G
T
G
A
V
K
L
C
D
Sea Urchin
Strong. purpuratus
XP_794490
382
43817
I224
R
D
V
K
P
S
N
I
L
L
D
R
G
G
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
N198
H
R
D
I
K
P
S
N
L
L
V
N
H
K
G
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
N496
T
N
I
L
C
S
A
N
Q
G
T
V
K
L
C
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.3
97.3
89.3
N.A.
97.9
41.7
N.A.
N.A.
36.5
77.3
48.3
N.A.
54
55.9
44.6
55.8
Protein Similarity:
100
53.6
97.3
90.5
N.A.
98.2
57.2
N.A.
N.A.
53.8
80.9
64.4
N.A.
65.8
68.8
61.6
71.1
P-Site Identity:
100
0
100
100
N.A.
100
80
N.A.
N.A.
20
86.6
6.6
N.A.
80
93.3
66.6
0
P-Site Similarity:
100
13.3
100
100
N.A.
100
80
N.A.
N.A.
26.6
93.3
13.3
N.A.
86.6
93.3
86.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
31
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.3
38.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
7
0
0
7
0
0
0
0
0
% A
% Cys:
0
0
0
0
7
0
0
0
0
0
0
0
0
60
7
% C
% Asp:
0
7
7
0
0
54
0
0
0
7
14
0
0
0
67
% D
% Glu:
0
0
7
0
0
0
14
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
14
0
60
7
7
0
7
7
7
% G
% His:
7
7
0
0
0
7
0
7
14
0
0
0
14
0
0
% H
% Ile:
0
0
67
7
0
0
0
14
0
0
54
0
0
0
0
% I
% Lys:
0
0
0
7
7
0
0
0
0
0
0
60
14
7
0
% K
% Leu:
7
0
0
67
67
0
0
0
14
14
0
0
60
7
0
% L
% Met:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
67
0
7
0
0
7
20
0
40
0
7
0
0
7
% N
% Pro:
0
7
0
0
7
14
0
0
0
0
0
0
0
7
0
% P
% Gln:
0
0
0
0
0
7
0
0
7
14
0
0
7
0
0
% Q
% Arg:
14
7
0
7
0
0
40
20
0
7
0
7
0
0
0
% R
% Ser:
67
7
7
0
7
20
7
27
0
0
7
0
0
7
14
% S
% Thr:
7
0
0
0
0
0
7
14
0
0
7
7
0
0
0
% T
% Val:
0
0
7
0
7
0
7
0
0
0
14
20
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
0
0
0
0
7
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _