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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAP2K4 All Species: 18.18
Human Site: S288 Identified Species: 28.57
UniProt: P45985 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.21
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P45985 NP_003001.1 399 44288 S288 R Q G Y D V R S D V W S L G I
Chimpanzee Pan troglodytes Q9XT09 393 43428 D282 F G C Q V E G D A A E T P P R
Rhesus Macaque Macaca mulatta XP_001114292 410 45566 S299 R Q G Y D V R S D V W S L G I
Dog Lupus familis XP_546627 413 46697 S302 R Q G Y D V R S D V W S L G I
Cat Felis silvestris
Mouse Mus musculus P47809 397 44095 S286 R Q G Y D V R S D V W S L G I
Rat Rattus norvegicus Q4KSH7 419 47517 R302 T K P D Y D I R A D V W S L G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90891 398 44059 E288 V V D G A E G E S H S V S P W
Frog Xenopus laevis Q07192 446 50082 S335 R Q G Y D V R S D V W S L G I
Zebra Danio Brachydanio rerio Q9DGE0 361 40575 R251 K P Y M A P E R I N P E T N Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477353 424 47515 D308 K G Y D V R S D V W S L G I T
Honey Bee Apis mellifera XP_394054 436 49631 D323 K G Y D V R S D V W S L G I T
Nematode Worm Caenorhab. elegans Q20347 363 41178 W253 Y D V R S D V W S L G I T L Y
Sea Urchin Strong. purpuratus XP_794490 382 43817 G272 D P F Q S R P G Y D I R S D V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FJV0 356 39818 D246 R I S G S T Y D Y S S D I W S
Baker's Yeast Sacchar. cerevisiae P08018 668 72701 Q544 D R A T Y T V Q S D I W S L G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 35.3 97.3 89.3 N.A. 97.9 41.7 N.A. N.A. 36.5 77.3 48.3 N.A. 54 55.9 44.6 55.8
Protein Similarity: 100 53.6 97.3 90.5 N.A. 98.2 57.2 N.A. N.A. 53.8 80.9 64.4 N.A. 65.8 68.8 61.6 71.1
P-Site Identity: 100 0 100 100 N.A. 100 0 N.A. N.A. 0 100 0 N.A. 0 0 0 0
P-Site Similarity: 100 6.6 100 100 N.A. 100 6.6 N.A. N.A. 0 100 6.6 N.A. 6.6 6.6 6.6 6.6
Percent
Protein Identity: N.A. N.A. N.A. 31 28.2 N.A.
Protein Similarity: N.A. N.A. N.A. 48.3 38.9 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 14 0 0 0 14 7 0 0 0 0 0 % A
% Cys: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 14 7 7 20 34 14 0 27 34 20 0 7 0 7 0 % D
% Glu: 0 0 0 0 0 14 7 7 0 0 7 7 0 0 0 % E
% Phe: 7 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 20 34 14 0 0 14 7 0 0 7 0 14 34 14 % G
% His: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % H
% Ile: 0 7 0 0 0 0 7 0 7 0 14 7 7 14 34 % I
% Lys: 20 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 7 0 14 34 20 0 % L
% Met: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 7 0 0 0 7 0 % N
% Pro: 0 14 7 0 0 7 7 0 0 0 7 0 7 14 0 % P
% Gln: 0 34 0 14 0 0 0 7 0 0 0 0 0 0 7 % Q
% Arg: 40 7 0 7 0 20 34 14 0 0 0 7 0 0 7 % R
% Ser: 0 0 7 0 20 0 14 34 20 7 27 34 27 0 7 % S
% Thr: 7 0 0 7 0 14 0 0 0 0 0 7 14 0 14 % T
% Val: 7 7 7 0 20 34 14 0 14 34 7 7 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 7 0 14 34 14 0 7 7 % W
% Tyr: 7 0 20 34 14 0 7 0 14 0 0 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _