KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K4
All Species:
20.3
Human Site:
S331
Identified Species:
31.9
UniProt:
P45985
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P45985
NP_003001.1
399
44288
S331
D
P
P
Q
L
S
N
S
E
E
R
E
F
S
P
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
L325
V
N
E
P
P
P
K
L
P
S
G
V
F
S
L
Rhesus Macaque
Macaca mulatta
XP_001114292
410
45566
S342
D
P
P
Q
L
S
N
S
E
E
R
E
F
S
P
Dog
Lupus familis
XP_546627
413
46697
S345
D
P
P
Q
L
S
N
S
E
E
R
E
F
S
P
Cat
Felis silvestris
Mouse
Mus musculus
P47809
397
44095
S329
D
P
P
Q
L
S
N
S
E
E
R
E
F
S
P
Rat
Rattus norvegicus
Q4KSH7
419
47517
G345
E
E
P
P
L
L
P
G
H
M
G
F
S
G
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90891
398
44059
L331
V
N
E
P
P
P
K
L
P
N
G
V
F
T
Q
Frog
Xenopus laevis
Q07192
446
50082
S378
D
P
P
Q
L
S
N
S
E
E
R
E
F
S
P
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
L294
W
G
T
P
F
Q
Q
L
K
Q
V
V
E
E
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477353
424
47515
Y351
P
P
R
L
L
T
S
Y
N
G
M
E
F
S
K
Honey Bee
Apis mellifera
XP_394054
436
49631
E366
P
P
R
L
S
P
N
E
N
G
N
H
F
T
M
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
D296
I
L
H
P
D
S
D
D
F
H
Y
S
L
P
L
Sea Urchin
Strong. purpuratus
XP_794490
382
43817
P315
Q
V
V
K
G
D
P
P
R
L
K
H
N
D
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
E289
E
L
L
A
A
I
V
E
N
P
P
P
T
A
P
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
L587
V
D
G
P
P
P
R
L
P
S
D
K
F
S
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.3
97.3
89.3
N.A.
97.9
41.7
N.A.
N.A.
36.5
77.3
48.3
N.A.
54
55.9
44.6
55.8
Protein Similarity:
100
53.6
97.3
90.5
N.A.
98.2
57.2
N.A.
N.A.
53.8
80.9
64.4
N.A.
65.8
68.8
61.6
71.1
P-Site Identity:
100
13.3
100
100
N.A.
100
13.3
N.A.
N.A.
6.6
100
6.6
N.A.
33.3
20
6.6
0
P-Site Similarity:
100
13.3
100
100
N.A.
100
20
N.A.
N.A.
13.3
100
20
N.A.
46.6
26.6
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
31
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.3
38.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
7
0
0
0
0
0
0
0
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
34
7
0
0
7
7
7
7
0
0
7
0
0
7
7
% D
% Glu:
14
7
14
0
0
0
0
14
34
34
0
40
7
7
0
% E
% Phe:
0
0
0
0
7
0
0
0
7
0
0
7
67
0
0
% F
% Gly:
0
7
7
0
7
0
0
7
0
14
20
0
0
7
0
% G
% His:
0
0
7
0
0
0
0
0
7
7
0
14
0
0
0
% H
% Ile:
7
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
7
0
0
14
0
7
0
7
7
0
0
14
% K
% Leu:
0
14
7
14
47
7
0
27
0
7
0
0
7
0
14
% L
% Met:
0
0
0
0
0
0
0
0
0
7
7
0
0
0
7
% M
% Asn:
0
14
0
0
0
0
40
0
20
7
7
0
7
0
0
% N
% Pro:
14
47
40
40
20
27
14
7
20
7
7
7
0
7
47
% P
% Gln:
7
0
0
34
0
7
7
0
0
7
0
0
0
0
7
% Q
% Arg:
0
0
14
0
0
0
7
0
7
0
34
0
0
0
0
% R
% Ser:
0
0
0
0
7
40
7
34
0
14
0
7
7
54
7
% S
% Thr:
0
0
7
0
0
7
0
0
0
0
0
0
7
14
0
% T
% Val:
20
7
7
0
0
0
7
0
0
0
7
20
0
0
0
% V
% Trp:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
7
0
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _