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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K4
All Species:
20.91
Human Site:
S339
Identified Species:
32.86
UniProt:
P45985
Number Species:
14
Phosphosite Substitution
Charge Score:
0.36
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P45985
NP_003001.1
399
44288
S339
E
E
R
E
F
S
P
S
F
I
N
F
V
N
L
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
E333
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
Rhesus Macaque
Macaca mulatta
XP_001114292
410
45566
S350
E
E
R
E
F
S
P
S
F
I
N
F
V
N
L
Dog
Lupus familis
XP_546627
413
46697
S353
E
E
R
E
F
S
P
S
F
I
N
F
V
N
L
Cat
Felis silvestris
Mouse
Mus musculus
P47809
397
44095
S337
E
E
R
E
F
S
P
S
F
I
N
F
V
N
L
Rat
Rattus norvegicus
Q4KSH7
419
47517
F353
H
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90891
398
44059
D339
P
N
G
V
F
T
Q
D
F
Q
E
F
V
N
K
Frog
Xenopus laevis
Q07192
446
50082
S386
E
E
R
E
F
S
P
S
F
T
S
F
V
N
Q
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
S302
K
Q
V
V
E
E
P
S
P
Q
L
P
A
D
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477353
424
47515
E359
N
G
M
E
F
S
K
E
F
V
D
F
V
N
T
Honey Bee
Apis mellifera
XP_394054
436
49631
D374
N
G
N
H
F
T
M
D
F
V
N
F
V
N
T
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
V304
F
H
Y
S
L
P
L
V
K
F
I
N
T
C
L
Sea Urchin
Strong. purpuratus
XP_794490
382
43817
Y323
R
L
K
H
N
D
K
Y
S
Y
S
E
D
F
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
S297
N
P
P
P
T
A
P
S
D
Q
F
S
P
E
F
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
D595
P
S
D
K
F
S
S
D
A
Q
D
F
V
S
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.3
97.3
89.3
N.A.
97.9
41.7
N.A.
N.A.
36.5
77.3
48.3
N.A.
54
55.9
44.6
55.8
Protein Similarity:
100
53.6
97.3
90.5
N.A.
98.2
57.2
N.A.
N.A.
53.8
80.9
64.4
N.A.
65.8
68.8
61.6
71.1
P-Site Identity:
100
40
100
100
N.A.
100
0
N.A.
N.A.
33.3
80
13.3
N.A.
46.6
40
6.6
0
P-Site Similarity:
100
46.6
100
100
N.A.
100
6.6
N.A.
N.A.
40
86.6
33.3
N.A.
60
53.3
6.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
31
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.3
38.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
7
0
0
7
0
0
0
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
7
% C
% Asp:
0
0
7
0
0
7
7
20
7
0
20
0
7
14
0
% D
% Glu:
34
34
0
40
7
7
0
14
0
0
7
7
0
7
0
% E
% Phe:
7
0
0
7
67
0
0
7
60
7
14
67
0
7
7
% F
% Gly:
0
14
20
0
0
7
0
0
0
0
0
0
0
0
0
% G
% His:
7
7
0
14
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
27
7
0
0
0
7
% I
% Lys:
7
0
7
7
0
0
14
0
7
0
0
0
7
0
14
% K
% Leu:
0
7
0
0
7
0
14
0
0
0
7
0
0
0
40
% L
% Met:
0
7
7
0
0
0
7
0
0
0
0
0
0
0
0
% M
% Asn:
20
7
7
0
7
0
0
0
0
0
34
7
0
60
0
% N
% Pro:
20
7
7
7
0
7
47
0
7
0
0
7
7
0
0
% P
% Gln:
0
7
0
0
0
0
7
0
7
34
0
0
0
0
7
% Q
% Arg:
7
0
34
0
0
0
0
0
0
0
0
0
0
0
7
% R
% Ser:
0
14
0
7
7
54
7
47
7
7
14
7
0
7
0
% S
% Thr:
0
0
0
0
7
14
0
0
0
7
0
0
7
0
14
% T
% Val:
0
0
7
20
0
0
0
7
0
14
0
7
67
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
0
0
7
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _