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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAP2K4 All Species: 24.24
Human Site: S353 Identified Species: 38.1
UniProt: P45985 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P45985 NP_003001.1 399 44288 S353 L C L T K D E S K R P K Y K E
Chimpanzee Pan troglodytes Q9XT09 393 43428 A347 K C L I K N P A E R A D L K Q
Rhesus Macaque Macaca mulatta XP_001114292 410 45566 S364 L C L T K D E S K R P K Y K E
Dog Lupus familis XP_546627 413 46697 S367 L C L T K D E S K R P K Y K E
Cat Felis silvestris
Mouse Mus musculus P47809 397 44095 S351 L C L T K D E S K R P K Y K E
Rat Rattus norvegicus Q4KSH7 419 47517 K367 C L T K D H R K R P K Y N K L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90891 398 44059 A353 K C L I K N P A E R A D L K M
Frog Xenopus laevis Q07192 446 50082 S400 Q C L T K D E S K R P K Y K E
Zebra Danio Brachydanio rerio Q9DGE0 361 40575 D316 R F S A D F V D F T S Q C L R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477353 424 47515 S373 T C L I K K E S D R P K Y S R
Honey Bee Apis mellifera XP_394054 436 49631 T388 T C L I K E E T Q R P K Y N K
Nematode Worm Caenorhab. elegans Q20347 363 41178 R318 L T K D R R H R P K Y D T L K
Sea Urchin Strong. purpuratus XP_794490 382 43817 L337 I S F V N K C L T K D E K Y R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FJV0 356 39818 C311 F C S F V S A C I Q K D P P A
Baker's Yeast Sacchar. cerevisiae P08018 668 72701 E609 L C L Q K I P E R R P T Y A A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 35.3 97.3 89.3 N.A. 97.9 41.7 N.A. N.A. 36.5 77.3 48.3 N.A. 54 55.9 44.6 55.8
Protein Similarity: 100 53.6 97.3 90.5 N.A. 98.2 57.2 N.A. N.A. 53.8 80.9 64.4 N.A. 65.8 68.8 61.6 71.1
P-Site Identity: 100 33.3 100 100 N.A. 100 6.6 N.A. N.A. 33.3 93.3 0 N.A. 60 53.3 6.6 0
P-Site Similarity: 100 60 100 100 N.A. 100 13.3 N.A. N.A. 53.3 93.3 6.6 N.A. 60 80 26.6 20
Percent
Protein Identity: N.A. N.A. N.A. 31 28.2 N.A.
Protein Similarity: N.A. N.A. N.A. 48.3 38.9 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 46.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 7 0 0 7 14 0 0 14 0 0 7 14 % A
% Cys: 7 74 0 0 0 0 7 7 0 0 0 0 7 0 0 % C
% Asp: 0 0 0 7 14 34 0 7 7 0 7 27 0 0 0 % D
% Glu: 0 0 0 0 0 7 47 7 14 0 0 7 0 0 34 % E
% Phe: 7 7 7 7 0 7 0 0 7 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 7 7 0 0 0 0 0 0 0 0 % H
% Ile: 7 0 0 27 0 7 0 0 7 0 0 0 0 0 0 % I
% Lys: 14 0 7 7 67 14 0 7 34 14 14 47 7 54 14 % K
% Leu: 40 7 67 0 0 0 0 7 0 0 0 0 14 14 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % M
% Asn: 0 0 0 0 7 14 0 0 0 0 0 0 7 7 0 % N
% Pro: 0 0 0 0 0 0 20 0 7 7 54 0 7 7 0 % P
% Gln: 7 0 0 7 0 0 0 0 7 7 0 7 0 0 7 % Q
% Arg: 7 0 0 0 7 7 7 7 14 67 0 0 0 0 20 % R
% Ser: 0 7 14 0 0 7 0 40 0 0 7 0 0 7 0 % S
% Thr: 14 7 7 34 0 0 0 7 7 7 0 7 7 0 0 % T
% Val: 0 0 0 7 7 0 7 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 7 7 54 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _