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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K4
All Species:
30.91
Human Site:
T136
Identified Species:
48.57
UniProt:
P45985
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P45985
NP_003001.1
399
44288
T136
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
C142
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
Rhesus Macaque
Macaca mulatta
XP_001114292
410
45566
T147
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Dog
Lupus familis
XP_546627
413
46697
T150
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Cat
Felis silvestris
Mouse
Mus musculus
P47809
397
44095
T134
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Rat
Rattus norvegicus
Q4KSH7
419
47517
S154
A
V
K
Q
M
R
R
S
G
N
K
E
E
N
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90891
398
44059
C144
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
Frog
Xenopus laevis
Q07192
446
50082
T183
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
I111
V
I
M
A
V
K
R
I
R
A
T
V
N
T
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477353
424
47515
T156
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Honey Bee
Apis mellifera
XP_394054
436
49631
T171
A
V
K
R
I
R
S
T
V
D
E
R
E
Q
K
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
E113
E
Q
I
R
L
L
R
E
H
D
T
I
V
K
S
Sea Urchin
Strong. purpuratus
XP_794490
382
43817
K132
T
V
D
E
K
D
Q
K
Q
L
L
M
D
L
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
Q106
K
V
I
Q
M
N
I
Q
E
E
I
R
K
Q
I
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
E394
A
T
K
E
V
R
L
E
L
D
E
A
K
F
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.3
97.3
89.3
N.A.
97.9
41.7
N.A.
N.A.
36.5
77.3
48.3
N.A.
54
55.9
44.6
55.8
Protein Similarity:
100
53.6
97.3
90.5
N.A.
98.2
57.2
N.A.
N.A.
53.8
80.9
64.4
N.A.
65.8
68.8
61.6
71.1
P-Site Identity:
100
6.6
100
100
N.A.
100
40
N.A.
N.A.
6.6
100
0
N.A.
100
93.3
13.3
6.6
P-Site Similarity:
100
33.3
100
100
N.A.
100
80
N.A.
N.A.
33.3
100
26.6
N.A.
100
100
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
31
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.3
38.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
60
0
0
7
0
0
0
0
0
7
0
7
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
14
0
0
0
0
0
0
0
% C
% Asp:
0
14
7
0
0
7
0
0
0
60
0
0
20
0
7
% D
% Glu:
7
0
0
27
0
0
0
14
7
20
54
7
54
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% F
% Gly:
0
0
14
0
0
0
0
0
7
0
0
0
0
14
14
% G
% His:
0
0
0
0
0
0
0
0
7
0
14
0
0
0
0
% H
% Ile:
0
7
14
0
60
0
20
7
0
0
7
7
0
0
7
% I
% Lys:
7
0
60
0
7
7
0
7
0
0
7
40
14
7
54
% K
% Leu:
0
0
0
0
7
7
7
0
7
7
7
0
0
7
0
% L
% Met:
0
0
7
0
14
0
0
0
14
0
0
20
0
0
0
% M
% Asn:
0
0
0
0
0
7
0
0
0
7
0
0
7
7
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
7
0
14
0
0
7
7
7
0
0
0
0
54
7
% Q
% Arg:
0
0
0
54
0
60
20
0
7
0
0
14
0
0
7
% R
% Ser:
14
0
0
0
0
14
47
7
0
0
0
0
0
0
7
% S
% Thr:
7
7
0
0
0
0
0
47
0
0
14
0
0
7
0
% T
% Val:
7
67
0
0
14
0
0
0
47
0
0
7
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _