KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K4
All Species:
34.24
Human Site:
T261
Identified Species:
53.81
UniProt:
P45985
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P45985
NP_003001.1
399
44288
T261
L
V
D
S
I
A
K
T
R
D
A
G
C
R
P
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
E255
S
M
G
L
S
P
V
E
M
A
V
G
R
Y
P
Rhesus Macaque
Macaca mulatta
XP_001114292
410
45566
T272
L
V
D
S
I
A
K
T
R
D
A
G
C
R
P
Dog
Lupus familis
XP_546627
413
46697
T275
L
V
D
S
I
A
K
T
R
D
A
G
C
R
P
Cat
Felis silvestris
Mouse
Mus musculus
P47809
397
44095
T259
L
V
D
S
I
A
K
T
R
D
A
G
C
R
P
Rat
Rattus norvegicus
Q4KSH7
419
47517
T275
L
V
D
S
K
A
K
T
R
S
A
G
C
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90891
398
44059
G261
S
L
V
E
L
S
I
G
R
Y
P
I
P
P
P
Frog
Xenopus laevis
Q07192
446
50082
T308
L
V
D
S
I
A
K
T
R
D
A
G
C
R
P
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
D224
Q
G
Q
V
K
M
C
D
F
G
I
S
G
Y
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477353
424
47515
T281
L
V
D
S
I
A
K
T
K
D
A
G
C
R
P
Honey Bee
Apis mellifera
XP_394054
436
49631
T296
L
V
D
S
I
A
R
T
R
D
A
G
C
R
P
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
T226
L
E
E
S
F
A
K
T
H
D
A
G
C
Q
P
Sea Urchin
Strong. purpuratus
XP_794490
382
43817
D245
G
I
S
G
Q
L
V
D
S
I
A
R
T
M
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
A219
F
G
V
S
A
S
L
A
S
S
M
G
Q
R
D
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
K517
N
L
V
A
S
L
A
K
T
N
I
G
C
Q
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.3
97.3
89.3
N.A.
97.9
41.7
N.A.
N.A.
36.5
77.3
48.3
N.A.
54
55.9
44.6
55.8
Protein Similarity:
100
53.6
97.3
90.5
N.A.
98.2
57.2
N.A.
N.A.
53.8
80.9
64.4
N.A.
65.8
68.8
61.6
71.1
P-Site Identity:
100
13.3
100
100
N.A.
100
73.3
N.A.
N.A.
13.3
100
0
N.A.
93.3
93.3
66.6
6.6
P-Site Similarity:
100
20
100
100
N.A.
100
73.3
N.A.
N.A.
33.3
100
0
N.A.
100
100
80
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
31
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.3
38.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
7
60
7
7
0
7
67
0
0
7
7
% A
% Cys:
0
0
0
0
0
0
7
0
0
0
0
0
67
0
0
% C
% Asp:
0
0
54
0
0
0
0
14
0
54
0
0
0
0
14
% D
% Glu:
0
7
7
7
0
0
0
7
0
0
0
0
0
0
0
% E
% Phe:
7
0
0
0
7
0
0
0
7
0
0
0
0
0
0
% F
% Gly:
7
14
7
7
0
0
0
7
0
7
0
80
7
0
0
% G
% His:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
47
0
7
0
0
7
14
7
0
0
0
% I
% Lys:
0
0
0
0
14
0
54
7
7
0
0
0
0
0
0
% K
% Leu:
60
14
0
7
7
14
7
0
0
0
0
0
0
0
7
% L
% Met:
0
7
0
0
0
7
0
0
7
0
7
0
0
7
0
% M
% Asn:
7
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
7
0
0
0
0
7
0
7
7
67
% P
% Gln:
7
0
7
0
7
0
0
0
0
0
0
0
7
14
0
% Q
% Arg:
0
0
0
0
0
0
7
0
54
0
0
7
7
54
0
% R
% Ser:
14
0
7
67
14
14
0
0
14
14
0
7
0
0
7
% S
% Thr:
0
0
0
0
0
0
0
60
7
0
0
0
7
0
0
% T
% Val:
0
54
20
7
0
0
14
0
0
0
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
7
0
0
0
14
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _