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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K4
All Species:
17.88
Human Site:
T349
Identified Species:
28.1
UniProt:
P45985
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P45985
NP_003001.1
399
44288
T349
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
I343
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
Rhesus Macaque
Macaca mulatta
XP_001114292
410
45566
T360
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
Dog
Lupus familis
XP_546627
413
46697
T363
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
Cat
Felis silvestris
Mouse
Mus musculus
P47809
397
44095
T347
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
Rat
Rattus norvegicus
Q4KSH7
419
47517
K363
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90891
398
44059
I349
E
F
V
N
K
C
L
I
K
N
P
A
E
R
A
Frog
Xenopus laevis
Q07192
446
50082
T396
S
F
V
N
Q
C
L
T
K
D
E
S
K
R
P
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
A312
L
P
A
D
R
F
S
A
D
F
V
D
F
T
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477353
424
47515
I369
D
F
V
N
T
C
L
I
K
K
E
S
D
R
P
Honey Bee
Apis mellifera
XP_394054
436
49631
I384
N
F
V
N
T
C
L
I
K
E
E
T
Q
R
P
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
D314
I
N
T
C
L
T
K
D
R
R
H
R
P
K
Y
Sea Urchin
Strong. purpuratus
XP_794490
382
43817
V333
S
E
D
F
I
S
F
V
N
K
C
L
T
K
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
F307
F
S
P
E
F
C
S
F
V
S
A
C
I
Q
K
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
Q605
D
F
V
S
L
C
L
Q
K
I
P
E
R
R
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.3
97.3
89.3
N.A.
97.9
41.7
N.A.
N.A.
36.5
77.3
48.3
N.A.
54
55.9
44.6
55.8
Protein Similarity:
100
53.6
97.3
90.5
N.A.
98.2
57.2
N.A.
N.A.
53.8
80.9
64.4
N.A.
65.8
68.8
61.6
71.1
P-Site Identity:
100
46.6
100
100
N.A.
100
0
N.A.
N.A.
46.6
86.6
0
N.A.
66.6
66.6
6.6
0
P-Site Similarity:
100
73.3
100
100
N.A.
100
13.3
N.A.
N.A.
66.6
93.3
6.6
N.A.
73.3
86.6
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
31
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.3
38.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
53.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
0
0
0
7
0
0
7
14
0
0
14
% A
% Cys:
0
0
0
7
7
74
0
0
0
0
7
7
0
0
0
% C
% Asp:
20
0
7
14
0
0
0
7
14
34
0
7
7
0
7
% D
% Glu:
7
7
0
7
0
0
0
0
0
7
47
7
14
0
0
% E
% Phe:
14
67
0
7
7
7
7
7
0
7
0
0
7
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
7
7
0
0
0
0
% H
% Ile:
7
0
0
0
7
0
0
27
0
7
0
0
7
0
0
% I
% Lys:
0
0
7
0
14
0
7
7
67
14
0
7
34
14
14
% K
% Leu:
7
0
0
0
40
7
67
0
0
0
0
7
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
34
7
0
60
0
0
0
0
7
14
0
0
0
0
0
% N
% Pro:
0
7
7
0
0
0
0
0
0
0
20
0
7
7
54
% P
% Gln:
0
0
0
0
7
0
0
7
0
0
0
0
7
7
0
% Q
% Arg:
0
0
0
0
7
0
0
0
7
7
7
7
14
67
0
% R
% Ser:
14
7
0
7
0
7
14
0
0
7
0
40
0
0
7
% S
% Thr:
0
0
7
0
14
7
7
34
0
0
0
7
7
7
0
% T
% Val:
0
7
67
0
0
0
0
7
7
0
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _