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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K4
All Species:
20
Human Site:
T391
Identified Species:
31.43
UniProt:
P45985
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P45985
NP_003001.1
399
44288
T391
I
L
D
Q
M
P
A
T
P
S
S
P
M
Y
V
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
S385
T
I
G
L
N
Q
P
S
T
P
T
H
A
A
G
Rhesus Macaque
Macaca mulatta
XP_001114292
410
45566
T402
I
L
D
Q
M
P
A
T
P
S
S
P
M
Y
V
Dog
Lupus familis
XP_546627
413
46697
T405
I
L
D
Q
M
P
A
T
P
S
S
P
M
Y
V
Cat
Felis silvestris
Mouse
Mus musculus
P47809
397
44095
T389
I
L
D
Q
M
P
A
T
P
S
S
P
M
Y
V
Rat
Rattus norvegicus
Q4KSH7
419
47517
R405
M
A
K
T
E
S
P
R
T
S
G
V
L
S
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90891
398
44059
S391
T
L
R
L
N
Q
P
S
T
P
T
R
A
A
V
Frog
Xenopus laevis
Q07192
446
50082
S438
I
L
E
Q
M
P
V
S
P
S
S
P
M
Y
V
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
F354
K
D
T
D
V
A
S
F
V
K
T
I
L
G
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477353
424
47515
D411
I
L
E
S
M
E
K
D
G
I
T
Q
F
T
A
Honey Bee
Apis mellifera
XP_394054
436
49631
R426
V
L
D
N
M
V
L
R
G
L
T
P
F
T
T
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
N356
V
E
A
I
D
T
R
N
H
P
V
D
H
R
G
Sea Urchin
Strong. purpuratus
XP_794490
382
43817
L375
T
F
V
S
E
I
L
L
A
M
R
S
T
S
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
E349
G
I
L
V
G
T
L
E
P
P
V
N
Y
L
R
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
I647
R
L
E
R
R
N
K
I
L
R
E
R
G
E
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.3
97.3
89.3
N.A.
97.9
41.7
N.A.
N.A.
36.5
77.3
48.3
N.A.
54
55.9
44.6
55.8
Protein Similarity:
100
53.6
97.3
90.5
N.A.
98.2
57.2
N.A.
N.A.
53.8
80.9
64.4
N.A.
65.8
68.8
61.6
71.1
P-Site Identity:
100
0
100
100
N.A.
100
6.6
N.A.
N.A.
13.3
80
0
N.A.
20
26.6
0
0
P-Site Similarity:
100
20
100
100
N.A.
100
20
N.A.
N.A.
26.6
93.3
26.6
N.A.
33.3
40
6.6
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
31
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.3
38.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
0
0
7
27
0
7
0
0
0
14
14
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
34
7
7
0
0
7
0
0
0
7
0
0
7
% D
% Glu:
0
7
20
0
14
7
0
7
0
0
7
0
0
7
0
% E
% Phe:
0
7
0
0
0
0
0
7
0
0
0
0
14
0
0
% F
% Gly:
7
0
7
0
7
0
0
0
14
0
7
0
7
7
14
% G
% His:
0
0
0
0
0
0
0
0
7
0
0
7
7
0
0
% H
% Ile:
40
14
0
7
0
7
0
7
0
7
0
7
0
0
0
% I
% Lys:
7
0
7
0
0
0
14
0
0
7
0
0
0
0
0
% K
% Leu:
0
60
7
14
0
0
20
7
7
7
0
0
14
7
0
% L
% Met:
7
0
0
0
47
0
0
0
0
7
0
0
34
0
0
% M
% Asn:
0
0
0
7
14
7
0
7
0
0
0
7
0
0
7
% N
% Pro:
0
0
0
0
0
34
20
0
40
27
0
40
0
0
0
% P
% Gln:
0
0
0
34
0
14
0
0
0
0
0
7
0
0
14
% Q
% Arg:
7
0
7
7
7
0
7
14
0
7
7
14
0
7
7
% R
% Ser:
0
0
0
14
0
7
7
20
0
40
34
7
0
14
0
% S
% Thr:
20
0
7
7
0
14
0
27
20
0
34
0
7
14
7
% T
% Val:
14
0
7
7
7
7
7
0
7
0
14
7
0
0
40
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
7
34
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _