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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAP2K4 All Species: 20.3
Human Site: T78 Identified Species: 31.9
UniProt: P45985 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P45985 NP_003001.1 399 44288 T78 P H I E R L R T H S I E S S G
Chimpanzee Pan troglodytes Q9XT09 393 43428 K84 G N G G V V F K V S H K P S G
Rhesus Macaque Macaca mulatta XP_001114292 410 45566 T89 P H I E R L R T H S I E S S G
Dog Lupus familis XP_546627 413 46697 T92 P H I E R L R T H S I E S S G
Cat Felis silvestris
Mouse Mus musculus P47809 397 44095 T76 P H I E R L R T H S I E S S G
Rat Rattus norvegicus Q4KSH7 419 47517 L96 S I E I D Q K L Q E I M K Q T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90891 398 44059 K86 G N G G V V T K V Q H K P S G
Frog Xenopus laevis Q07192 446 50082 T125 N R L E R L R T H S I E S S G
Zebra Danio Brachydanio rerio Q9DGE0 361 40575 A53 V F E K P A P A P T P P R D L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477353 424 47515 R98 D R H R E R I R Q Q A C G K L
Honey Bee Apis mellifera XP_394054 436 49631 C113 A R D K L R M C Q S M Q S T G
Nematode Worm Caenorhab. elegans Q20347 363 41178 D55 G T L K Y P D D E H L Y T F S
Sea Urchin Strong. purpuratus XP_794490 382 43817 Y74 D E Y E G L E Y F T V S P I V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FJV0 356 39818 S48 Q K G L R L T S D E K Q S R Q
Baker's Yeast Sacchar. cerevisiae P08018 668 72701 G336 S G S L N F A G K L S L S S K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 35.3 97.3 89.3 N.A. 97.9 41.7 N.A. N.A. 36.5 77.3 48.3 N.A. 54 55.9 44.6 55.8
Protein Similarity: 100 53.6 97.3 90.5 N.A. 98.2 57.2 N.A. N.A. 53.8 80.9 64.4 N.A. 65.8 68.8 61.6 71.1
P-Site Identity: 100 20 100 100 N.A. 100 6.6 N.A. N.A. 13.3 80 0 N.A. 0 20 0 13.3
P-Site Similarity: 100 40 100 100 N.A. 100 13.3 N.A. N.A. 33.3 86.6 13.3 N.A. 0 46.6 26.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. 31 28.2 N.A.
Protein Similarity: N.A. N.A. N.A. 48.3 38.9 N.A.
P-Site Identity: N.A. N.A. N.A. 20 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 0 7 7 7 0 0 7 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 7 0 0 0 7 0 0 0 % C
% Asp: 14 0 7 0 7 0 7 7 7 0 0 0 0 7 0 % D
% Glu: 0 7 14 40 7 0 7 0 7 14 0 34 0 0 0 % E
% Phe: 0 7 0 0 0 7 7 0 7 0 0 0 0 7 0 % F
% Gly: 20 7 20 14 7 0 0 7 0 0 0 0 7 0 54 % G
% His: 0 27 7 0 0 0 0 0 34 7 14 0 0 0 0 % H
% Ile: 0 7 27 7 0 0 7 0 0 0 40 0 0 7 0 % I
% Lys: 0 7 0 20 0 0 7 14 7 0 7 14 7 7 7 % K
% Leu: 0 0 14 14 7 47 0 7 0 7 7 7 0 0 14 % L
% Met: 0 0 0 0 0 0 7 0 0 0 7 7 0 0 0 % M
% Asn: 7 14 0 0 7 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 27 0 0 0 7 7 7 0 7 0 7 7 20 0 0 % P
% Gln: 7 0 0 0 0 7 0 0 20 14 0 14 0 7 7 % Q
% Arg: 0 20 0 7 40 14 34 7 0 0 0 0 7 7 0 % R
% Ser: 14 0 7 0 0 0 0 7 0 47 7 7 54 54 7 % S
% Thr: 0 7 0 0 0 0 14 34 0 14 0 0 7 7 7 % T
% Val: 7 0 0 0 14 14 0 0 14 0 7 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 7 0 7 0 0 7 0 0 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _