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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K4
All Species:
26.06
Human Site:
T98
Identified Species:
40.95
UniProt:
P45985
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P45985
NP_003001.1
399
44288
T98
P
E
Q
H
W
D
F
T
A
E
D
L
K
D
L
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
K104
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
Rhesus Macaque
Macaca mulatta
XP_001114292
410
45566
T109
P
E
Q
H
W
D
F
T
A
E
D
L
K
D
L
Dog
Lupus familis
XP_546627
413
46697
T112
P
E
Q
H
W
D
F
T
A
E
D
L
K
D
L
Cat
Felis silvestris
Mouse
Mus musculus
P47809
397
44095
T96
P
E
Q
H
W
D
F
T
A
E
D
L
K
D
L
Rat
Rattus norvegicus
Q4KSH7
419
47517
E116
G
G
Q
R
Y
Q
A
E
I
N
D
L
E
N
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90891
398
44059
K106
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
Frog
Xenopus laevis
Q07192
446
50082
T145
P
E
Q
H
W
D
F
T
A
E
D
L
K
D
L
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
F73
V
T
I
G
E
K
N
F
V
V
K
A
D
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477353
424
47515
T118
G
A
N
T
H
T
F
T
S
D
D
L
E
D
E
Honey Bee
Apis mellifera
XP_394054
436
49631
T133
P
N
A
V
Y
D
F
T
S
E
D
L
Q
D
L
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
G75
D
L
G
A
I
G
N
G
N
F
G
T
V
Y
K
Sea Urchin
Strong. purpuratus
XP_794490
382
43817
M94
T
S
A
D
L
E
D
M
G
E
I
G
R
G
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
E68
L
D
F
E
I
T
A
E
D
L
E
T
V
K
V
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
T356
N
G
S
S
S
R
I
T
L
D
E
L
E
F
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.3
97.3
89.3
N.A.
97.9
41.7
N.A.
N.A.
36.5
77.3
48.3
N.A.
54
55.9
44.6
55.8
Protein Similarity:
100
53.6
97.3
90.5
N.A.
98.2
57.2
N.A.
N.A.
53.8
80.9
64.4
N.A.
65.8
68.8
61.6
71.1
P-Site Identity:
100
6.6
100
100
N.A.
100
26.6
N.A.
N.A.
6.6
100
13.3
N.A.
33.3
60
0
6.6
P-Site Similarity:
100
20
100
100
N.A.
100
46.6
N.A.
N.A.
20
100
13.3
N.A.
53.3
80
0
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
31
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.3
38.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
14
7
0
0
14
0
34
14
0
7
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
7
0
7
0
40
7
0
7
14
54
0
7
54
0
% D
% Glu:
0
34
0
7
7
20
0
14
0
47
14
0
20
0
7
% E
% Phe:
0
0
7
0
0
0
47
7
0
7
0
0
0
7
0
% F
% Gly:
14
14
7
7
0
7
0
7
7
0
7
7
0
7
0
% G
% His:
0
0
0
47
7
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
20
0
14
0
20
0
7
0
20
0
0
0
14
% I
% Lys:
14
0
0
0
0
7
0
14
0
0
7
0
34
7
7
% K
% Leu:
7
20
0
0
20
0
0
0
7
7
0
60
0
0
60
% L
% Met:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% M
% Asn:
7
7
7
0
0
0
14
0
7
7
0
0
14
7
0
% N
% Pro:
40
0
0
0
0
0
0
0
14
0
0
0
0
0
0
% P
% Gln:
0
0
40
0
0
7
0
0
0
0
0
0
7
14
0
% Q
% Arg:
0
0
0
7
0
7
0
0
0
0
0
14
7
0
0
% R
% Ser:
0
7
7
7
7
0
0
0
14
0
0
0
0
0
0
% S
% Thr:
7
7
0
7
0
14
0
54
0
0
0
14
0
0
0
% T
% Val:
7
0
0
7
0
0
0
0
7
7
0
0
14
0
7
% V
% Trp:
0
0
0
0
34
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
14
0
0
0
0
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _