KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K4
All Species:
29.09
Human Site:
Y160
Identified Species:
45.71
UniProt:
P45985
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P45985
NP_003001.1
399
44288
Y160
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
P162
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
Rhesus Macaque
Macaca mulatta
XP_001114292
410
45566
Y171
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
Dog
Lupus familis
XP_546627
413
46697
Y174
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
Cat
Felis silvestris
Mouse
Mus musculus
P47809
397
44095
Y158
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
Rat
Rattus norvegicus
Q4KSH7
419
47517
Y178
L
K
S
H
D
C
P
Y
I
V
Q
C
F
G
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90891
398
44059
P164
L
K
E
A
K
R
I
P
E
E
I
L
G
K
V
Frog
Xenopus laevis
Q07192
446
50082
Y207
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
M131
L
M
D
L
D
I
S
M
R
T
V
D
C
F
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477353
424
47515
Y180
M
K
S
N
E
C
I
Y
I
V
Q
F
Y
G
A
Honey Bee
Apis mellifera
XP_394054
436
49631
C195
M
K
S
N
E
C
P
C
I
V
Q
F
Y
G
A
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
I133
I
V
K
F
Y
G
A
I
F
S
E
G
D
C
W
Sea Urchin
Strong. purpuratus
XP_794490
382
43817
K152
A
N
C
V
Y
I
I
K
F
F
G
A
L
F
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
C126
I
N
Q
A
S
S
Q
C
P
H
V
V
V
C
Y
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
Y417
L
H
K
C
N
S
P
Y
I
V
D
F
Y
G
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.3
97.3
89.3
N.A.
97.9
41.7
N.A.
N.A.
36.5
77.3
48.3
N.A.
54
55.9
44.6
55.8
Protein Similarity:
100
53.6
97.3
90.5
N.A.
98.2
57.2
N.A.
N.A.
53.8
80.9
64.4
N.A.
65.8
68.8
61.6
71.1
P-Site Identity:
100
0
100
100
N.A.
100
60
N.A.
N.A.
0
100
6.6
N.A.
73.3
73.3
0
0
P-Site Similarity:
100
20
100
100
N.A.
100
80
N.A.
N.A.
20
100
13.3
N.A.
93.3
93.3
13.3
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
31
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.3
38.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
53.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
20
0
0
7
0
0
0
0
7
0
0
54
% A
% Cys:
0
0
7
7
0
54
0
14
0
0
0
7
7
14
0
% C
% Asp:
0
0
7
0
47
0
0
0
0
0
7
7
7
0
0
% D
% Glu:
0
0
7
0
14
0
0
0
14
7
7
0
0
0
0
% E
% Phe:
0
0
0
7
0
0
0
0
14
7
0
54
7
14
0
% F
% Gly:
0
0
0
0
7
7
0
0
0
0
7
7
14
60
0
% G
% His:
0
7
0
7
0
0
0
0
0
7
0
0
0
0
0
% H
% Ile:
14
0
0
0
0
14
27
7
60
0
14
0
0
0
0
% I
% Lys:
0
34
20
0
7
0
0
7
0
0
0
0
0
14
7
% K
% Leu:
34
0
0
7
0
0
0
0
0
0
0
14
7
0
0
% L
% Met:
47
7
0
0
0
0
0
7
0
0
0
0
0
0
0
% M
% Asn:
0
14
0
14
7
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
54
14
7
0
0
0
0
0
0
% P
% Gln:
0
0
7
0
0
0
7
0
0
7
54
0
0
0
0
% Q
% Arg:
0
34
0
0
0
14
0
0
7
0
0
0
0
0
0
% R
% Ser:
0
0
54
34
7
14
7
0
0
7
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
7
% T
% Val:
0
7
0
7
0
0
0
0
0
60
14
7
7
0
14
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% W
% Tyr:
0
0
0
0
14
0
0
54
0
0
0
0
54
0
14
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _