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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RECQL All Species: 10
Human Site: Y492 Identified Species: 15.71
UniProt: P46063 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P46063 NP_002898.2 649 73457 Y492 E R K N I T E Y C R D L I K I
Chimpanzee Pan troglodytes XP_520788 778 87498 Y621 E R K N I T E Y C R D L V K I
Rhesus Macaque Macaca mulatta XP_001094207 778 87626 Y621 E R K N I T E Y C R D L I K I
Dog Lupus familis XP_543768 646 73297 H492 E R K N V T A H C R D L V K I
Cat Felis silvestris
Mouse Mus musculus Q9Z129 648 72534 H492 E K K N V T Q H C R D L I K I
Rat Rattus norvegicus Q6AYJ1 621 69624 K480 K M C D N C C K D D S F E K K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q9I920 1142 126164 E810 K S R N V T D E V K S I I R F
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001038561 639 72081 H496 I T M D I T Q H A R D V L H I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VGI8 1487 166060 D1144 K R A Y K A V D A L E H A R K
Honey Bee Apis mellifera XP_396807 583 66843 T441 L A Y C L D Q T S C R R S L I
Nematode Worm Caenorhab. elegans Q9TXJ8 631 71078 W488 E E A W E P S W C Q K Q C D T
Sea Urchin Strong. purpuratus XP_786769 920 101596 K642 I E R K P P K K S G K S A K L
Poplar Tree Populus trichocarpa XP_002304389 718 80947 H493 M E V D V S R H A K V M V S L
Maize Zea mays NP_001168975 710 80077 H489 K D I D V T Y H T K I I V S L
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FT73 705 79350 L489 K E V D V S D L S K L V V S M
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.1 82.6 88.2 N.A. 84.9 79.6 N.A. N.A. 26.3 N.A. 56.5 N.A. 20.1 46 43.1 35.6
Protein Similarity: 100 83.4 83.2 93.9 N.A. 92.5 88.2 N.A. N.A. 37.7 N.A. 70.8 N.A. 30.6 63.7 61.3 49.3
P-Site Identity: 100 93.3 100 73.3 N.A. 73.3 6.6 N.A. N.A. 20 N.A. 33.3 N.A. 6.6 6.6 13.3 6.6
P-Site Similarity: 100 100 100 93.3 N.A. 100 20 N.A. N.A. 66.6 N.A. 66.6 N.A. 26.6 20 26.6 26.6
Percent
Protein Identity: 39.2 39.4 N.A. 39 N.A. N.A.
Protein Similarity: 58.6 57.4 N.A. 58.8 N.A. N.A.
P-Site Identity: 0 6.6 N.A. 0 N.A. N.A.
P-Site Similarity: 53.3 60 N.A. 60 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 14 0 0 7 7 0 20 0 0 0 14 0 0 % A
% Cys: 0 0 7 7 0 7 7 0 40 7 0 0 7 0 0 % C
% Asp: 0 7 0 34 0 7 14 7 7 7 40 0 0 7 0 % D
% Glu: 40 27 0 0 7 0 20 7 0 0 7 0 7 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 7 % F
% Gly: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 34 0 0 0 7 0 7 0 % H
% Ile: 14 0 7 0 27 0 0 0 0 0 7 14 27 0 47 % I
% Lys: 34 7 34 7 7 0 7 14 0 27 14 0 0 47 14 % K
% Leu: 7 0 0 0 7 0 0 7 0 7 7 34 7 7 20 % L
% Met: 7 7 7 0 0 0 0 0 0 0 0 7 0 0 7 % M
% Asn: 0 0 0 40 7 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 7 14 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 20 0 0 7 0 7 0 0 0 % Q
% Arg: 0 34 14 0 0 0 7 0 0 40 7 7 0 14 0 % R
% Ser: 0 7 0 0 0 14 7 0 20 0 14 7 7 20 0 % S
% Thr: 0 7 0 0 0 54 0 7 7 0 0 0 0 0 7 % T
% Val: 0 0 14 0 40 0 7 0 7 0 7 14 34 0 0 % V
% Trp: 0 0 0 7 0 0 0 7 0 0 0 0 0 0 0 % W
% Tyr: 0 0 7 7 0 0 7 20 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _