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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NOP2 All Species: 24.55
Human Site: S590 Identified Species: 41.54
UniProt: P46087 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P46087 NP_001028886.1 812 89302 S590 K F K K F S N S I P Q S Q T G
Chimpanzee Pan troglodytes XP_001162276 812 89269 S590 K F K K F S N S I P Q S Q T G
Rhesus Macaque Macaca mulatta XP_001105884 811 89266 S589 K F K K F S N S I P Q S E T G
Dog Lupus familis XP_854432 985 108067 S761 K F K K F S N S I P Q S Q T G
Cat Felis silvestris
Mouse Mus musculus Q922K7 793 86733 S575 K F K K F S N S I P Q P H A G
Rat Rattus norvegicus XP_235295 772 84951 S570 K F K K F S N S I P Q P H S G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_416502 682 76182 K483 I K T N K D E K D I L R C A H
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001922354 739 83513 V519 Y C T C S I M V E E N E W V V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_610786 891 99823 T641 K L K K F S N T I P I T K E Q
Honey Bee Apis mellifera XP_001121968 582 67009 A383 G G K S S H I A A L M K N T G
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_787141 1076 119756 K867 K L K K L S N K I P D S E K K
Poplar Tree Populus trichocarpa XP_002300386 476 53332 E277 V K I S K T S E D I E Q C A H
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_194390 671 75524 I472 N S K T G G Y I V Y S T C S V
Baker's Yeast Sacchar. cerevisiae P40991 618 69794 L419 I G G F D R I L L D A P C S G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 95.1 68.8 N.A. 75.8 75.1 N.A. N.A. 55.5 N.A. 53 N.A. 41 37.5 N.A. 37.4
Protein Similarity: 100 99.3 96.1 73.8 N.A. 83.2 82 N.A. N.A. 65.3 N.A. 66.5 N.A. 57.6 49.2 N.A. 49.7
P-Site Identity: 100 100 93.3 100 N.A. 80 80 N.A. N.A. 0 N.A. 0 N.A. 53.3 20 N.A. 53.3
P-Site Similarity: 100 100 100 100 N.A. 80 86.6 N.A. N.A. 0 N.A. 0 N.A. 73.3 26.6 N.A. 60
Percent
Protein Identity: 37.9 N.A. N.A. 39.7 37.4 N.A.
Protein Similarity: 47.6 N.A. N.A. 55.6 52 N.A.
P-Site Identity: 0 N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: 20 N.A. N.A. 26.6 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 8 8 0 8 0 0 22 0 % A
% Cys: 0 8 0 8 0 0 0 0 0 0 0 0 29 0 0 % C
% Asp: 0 0 0 0 8 8 0 0 15 8 8 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 8 8 8 8 8 8 15 8 0 % E
% Phe: 0 43 0 8 50 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 15 8 0 8 8 0 0 0 0 0 0 0 0 58 % G
% His: 0 0 0 0 0 8 0 0 0 0 0 0 15 0 15 % H
% Ile: 15 0 8 0 0 8 15 8 58 15 8 0 0 0 0 % I
% Lys: 58 15 72 58 15 0 0 15 0 0 0 8 8 8 8 % K
% Leu: 0 15 0 0 8 0 0 8 8 8 8 0 0 0 0 % L
% Met: 0 0 0 0 0 0 8 0 0 0 8 0 0 0 0 % M
% Asn: 8 0 0 8 0 0 58 0 0 0 8 0 8 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 58 0 22 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 43 8 22 0 8 % Q
% Arg: 0 0 0 0 0 8 0 0 0 0 0 8 0 0 0 % R
% Ser: 0 8 0 15 15 58 8 43 0 0 8 36 0 22 0 % S
% Thr: 0 0 15 8 0 8 0 8 0 0 0 15 0 36 0 % T
% Val: 8 0 0 0 0 0 0 8 8 0 0 0 0 8 15 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % W
% Tyr: 8 0 0 0 0 0 8 0 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _