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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTR3A
All Species:
12.73
Human Site:
S38
Identified Species:
31.11
UniProt:
P46098
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46098
NP_000860
478
55280
S38
R
P
A
L
L
R
L
S
D
Y
L
L
T
N
Y
Chimpanzee
Pan troglodytes
Q5IS51
468
53049
L51
A
K
H
E
D
S
L
L
K
D
L
F
Q
D
Y
Rhesus Macaque
Macaca mulatta
Q866A2
502
56411
Y30
G
E
F
Q
R
K
L
Y
K
E
L
V
K
N
Y
Dog
Lupus familis
XP_853967
442
50552
T32
N
S
A
L
Y
R
L
T
K
Q
L
L
Q
K
H
Cat
Felis silvestris
Mouse
Mus musculus
P23979
487
56038
S42
Q
P
A
L
L
R
L
S
D
H
L
L
A
N
Y
Rat
Rattus norvegicus
P35563
483
55410
S43
Q
P
A
L
L
R
L
S
D
H
L
L
A
N
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519474
387
44401
Chicken
Gallus gallus
Q9I8C7
452
50034
L36
G
R
L
A
H
K
L
L
H
D
L
F
A
N
Y
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_700338
466
53299
A31
R
L
N
E
F
L
S
A
G
Y
K
K
G
V
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U298
474
55023
D31
E
E
Y
R
L
L
K
D
L
R
E
G
Y
D
P
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
26.9
27.8
42.2
N.A.
83.3
84
N.A.
62.5
31.7
N.A.
63.5
N.A.
N.A.
N.A.
29.2
N.A.
Protein Similarity:
100
50
48
59.4
N.A.
90.3
90.8
N.A.
70.9
50.6
N.A.
76.1
N.A.
N.A.
N.A.
51.8
N.A.
P-Site Identity:
100
20
26.6
40
N.A.
80
80
N.A.
0
26.6
N.A.
13.3
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
26.6
40
53.3
N.A.
93.3
93.3
N.A.
0
33.3
N.A.
20
N.A.
N.A.
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
40
10
0
0
0
10
0
0
0
0
30
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
10
0
0
10
30
20
0
0
0
20
0
% D
% Glu:
10
20
0
20
0
0
0
0
0
10
10
0
0
0
0
% E
% Phe:
0
0
10
0
10
0
0
0
0
0
0
20
0
0
0
% F
% Gly:
20
0
0
0
0
0
0
0
10
0
0
10
10
0
0
% G
% His:
0
0
10
0
10
0
0
0
10
20
0
0
0
0
10
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
10
0
0
0
20
10
0
30
0
10
10
10
10
0
% K
% Leu:
0
10
10
40
40
20
70
20
10
0
70
40
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
10
0
0
0
0
0
0
0
0
0
0
50
0
% N
% Pro:
0
30
0
0
0
0
0
0
0
0
0
0
0
0
10
% P
% Gln:
20
0
0
10
0
0
0
0
0
10
0
0
20
0
0
% Q
% Arg:
20
10
0
10
10
40
0
0
0
10
0
0
0
0
10
% R
% Ser:
0
10
0
0
0
10
10
30
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
10
0
0
0
0
10
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
10
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
0
10
0
0
10
0
20
0
0
10
0
60
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _