KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTR3A
All Species:
16.06
Human Site:
S424
Identified Species:
39.26
UniProt:
P46098
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46098
NP_000860
478
55280
S424
G
L
L
Q
E
L
S
S
I
R
Q
F
L
E
K
Chimpanzee
Pan troglodytes
Q5IS51
468
53049
F422
E
V
V
E
D
W
K
F
I
A
Q
V
L
D
R
Rhesus Macaque
Macaca mulatta
Q866A2
502
56411
Y442
K
I
L
E
E
V
R
Y
I
A
N
R
F
R
C
Dog
Lupus familis
XP_853967
442
50552
E397
W
D
Q
S
D
Q
Q
E
V
K
W
L
A
L
L
Cat
Felis silvestris
Mouse
Mus musculus
P23979
487
56038
S433
G
L
L
Q
E
L
S
S
I
R
H
F
L
E
K
Rat
Rattus norvegicus
P35563
483
55410
S429
G
L
L
Q
E
L
S
S
I
R
H
S
L
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519474
387
44401
E342
R
R
F
L
E
R
R
E
E
C
R
D
I
S
R
Chicken
Gallus gallus
Q9I8C7
452
50034
Y403
A
V
L
S
S
V
G
Y
I
A
G
V
F
R
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_700338
466
53299
T412
G
I
L
R
E
I
T
T
I
R
Q
F
L
E
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U298
474
55023
V413
E
I
I
G
Y
L
K
V
F
K
A
K
L
D
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
26.9
27.8
42.2
N.A.
83.3
84
N.A.
62.5
31.7
N.A.
63.5
N.A.
N.A.
N.A.
29.2
N.A.
Protein Similarity:
100
50
48
59.4
N.A.
90.3
90.8
N.A.
70.9
50.6
N.A.
76.1
N.A.
N.A.
N.A.
51.8
N.A.
P-Site Identity:
100
20
20
0
N.A.
93.3
86.6
N.A.
6.6
13.3
N.A.
66.6
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
100
60
40
20
N.A.
93.3
86.6
N.A.
26.6
33.3
N.A.
100
N.A.
N.A.
N.A.
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
0
0
0
0
0
30
10
0
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
10
% C
% Asp:
0
10
0
0
20
0
0
0
0
0
0
10
0
20
10
% D
% Glu:
20
0
0
20
60
0
0
20
10
0
0
0
0
40
0
% E
% Phe:
0
0
10
0
0
0
0
10
10
0
0
30
20
0
0
% F
% Gly:
40
0
0
10
0
0
10
0
0
0
10
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
20
0
0
0
0
% H
% Ile:
0
30
10
0
0
10
0
0
70
0
0
0
10
0
0
% I
% Lys:
10
0
0
0
0
0
20
0
0
20
0
10
0
0
40
% K
% Leu:
0
30
60
10
0
40
0
0
0
0
0
10
60
10
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
10
30
0
10
10
0
0
0
30
0
0
0
0
% Q
% Arg:
10
10
0
10
0
10
20
0
0
40
10
10
0
20
30
% R
% Ser:
0
0
0
20
10
0
30
30
0
0
0
10
0
10
0
% S
% Thr:
0
0
0
0
0
0
10
10
0
0
0
0
0
0
0
% T
% Val:
0
20
10
0
0
20
0
10
10
0
0
20
0
0
0
% V
% Trp:
10
0
0
0
0
10
0
0
0
0
10
0
0
0
0
% W
% Tyr:
0
0
0
0
10
0
0
20
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _