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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CRKL
All Species:
28.18
Human Site:
Y105
Identified Species:
56.36
UniProt:
P46109
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46109
NP_005198.1
303
33777
Y105
L
I
E
P
A
P
R
Y
P
S
P
P
M
G
S
Chimpanzee
Pan troglodytes
XP_001167996
296
33105
S105
L
I
E
P
A
P
R
S
R
T
G
S
S
G
I
Rhesus Macaque
Macaca mulatta
XP_001086006
296
33190
S105
L
I
E
P
A
P
R
S
R
T
G
S
R
I
I
Dog
Lupus familis
XP_849949
303
33840
Y105
L
I
E
P
A
P
R
Y
P
S
P
P
M
G
S
Cat
Felis silvestris
Mouse
Mus musculus
P47941
303
33812
Y105
L
I
E
P
A
P
R
Y
P
S
P
P
V
G
S
Rat
Rattus norvegicus
Q5U2U2
303
33847
Y105
L
I
E
P
A
P
R
Y
P
N
P
P
M
G
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507507
300
33196
Y105
L
I
E
P
A
P
R
Y
A
T
P
P
I
G
S
Chicken
Gallus gallus
Q04929
305
33787
L115
H
Y
L
D
T
T
T
L
I
E
P
V
S
R
S
Frog
Xenopus laevis
P87378
296
33391
T107
I
H
Y
L
D
T
T
T
L
I
E
P
V
S
K
Zebra Danio
Brachydanio rerio
NP_998703
305
33802
Y105
L
I
E
P
A
P
R
Y
P
S
T
A
L
P
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9XYM0
271
31186
T98
T
L
H
Y
L
D
T
T
P
L
K
R
P
A
C
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9NHC3
279
30860
R102
L
L
N
H
F
K
M
R
V
L
T
E
A
S
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.7
95.3
97.3
N.A.
96.6
96.6
N.A.
90.4
60
61.7
82.6
N.A.
43.5
N.A.
27.7
N.A.
Protein Similarity:
100
96
96
98.6
N.A.
99
98.6
N.A.
94.3
71.8
72.9
90.8
N.A.
62.3
N.A.
45.2
N.A.
P-Site Identity:
100
53.3
46.6
100
N.A.
93.3
93.3
N.A.
80
13.3
6.6
73.3
N.A.
6.6
N.A.
6.6
N.A.
P-Site Similarity:
100
60
53.3
100
N.A.
100
100
N.A.
93.3
13.3
20
80
N.A.
13.3
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
67
0
0
0
9
0
0
9
9
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% C
% Asp:
0
0
0
9
9
9
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
67
0
0
0
0
0
0
9
9
9
0
0
0
% E
% Phe:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
17
0
0
50
0
% G
% His:
9
9
9
9
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
9
67
0
0
0
0
0
0
9
9
0
0
9
9
17
% I
% Lys:
0
0
0
0
0
9
0
0
0
0
9
0
0
0
9
% K
% Leu:
75
17
9
9
9
0
0
9
9
17
0
0
9
0
9
% L
% Met:
0
0
0
0
0
0
9
0
0
0
0
0
25
0
0
% M
% Asn:
0
0
9
0
0
0
0
0
0
9
0
0
0
0
0
% N
% Pro:
0
0
0
67
0
67
0
0
50
0
50
50
9
9
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
67
9
17
0
0
9
9
9
0
% R
% Ser:
0
0
0
0
0
0
0
17
0
34
0
17
17
17
59
% S
% Thr:
9
0
0
0
9
17
25
17
0
25
17
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
9
0
0
9
17
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
9
9
0
0
0
50
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _