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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MTIF2 All Species: 9.39
Human Site: T177 Identified Species: 17.22
UniProt: P46199 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P46199 NP_001005369.1 727 81317 T177 Q A D P A L L T P R S P V V T
Chimpanzee Pan troglodytes XP_001155121 727 81419 T177 Q A D P A L L T P R S P V V T
Rhesus Macaque Macaca mulatta XP_001114893 671 74635 S167 H I G A F L V S L P S G E K I
Dog Lupus familis XP_531830 727 81467 I177 Q A D P A L L I P R S P V V T
Cat Felis silvestris
Mouse Mus musculus Q91YJ5 727 81328 K177 G T D P A L L K P R S P V V T
Rat Rattus norvegicus NP_001004254 727 81236 K177 G A D P A L L K P R S P V V T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510159 744 83619 V195 K A D P A L L V P R S P V V T
Chicken Gallus gallus XP_419288 726 81476 T177 P A D P A F L T P R P P V V T
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001082793 705 78636 H166 P V V T I M G H I D H G K T T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651621 696 76771 Q159 P A A P E L L Q P R P P V V T
Honey Bee Apis mellifera NP_001011586 690 78106 D163 H G K T T L L D A L R N T S I
Nematode Worm Caenorhab. elegans NP_001023936 702 78116 H164 P I V T I M G H V D H G K T T
Sea Urchin Strong. purpuratus XP_001180329 739 82065 K194 P A D P S L L K L R P P V V T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 85.1 85.1 N.A. 81.2 83.3 N.A. 70 65.8 N.A. 57.6 N.A. 45.9 40.8 40.1 47.9
Protein Similarity: 100 99.8 89.4 92 N.A. 90.9 92.3 N.A. 82.3 80.6 N.A. 74.6 N.A. 63 60.5 59.4 65.7
P-Site Identity: 100 100 13.3 93.3 N.A. 80 86.6 N.A. 86.6 80 N.A. 6.6 N.A. 66.6 13.3 6.6 66.6
P-Site Similarity: 100 100 26.6 93.3 N.A. 80 86.6 N.A. 93.3 80 N.A. 13.3 N.A. 66.6 13.3 13.3 73.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 62 8 8 54 0 0 0 8 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 62 0 0 0 0 8 0 16 0 0 0 0 0 % D
% Glu: 0 0 0 0 8 0 0 0 0 0 0 0 8 0 0 % E
% Phe: 0 0 0 0 8 8 0 0 0 0 0 0 0 0 0 % F
% Gly: 16 8 8 0 0 0 16 0 0 0 0 24 0 0 0 % G
% His: 16 0 0 0 0 0 0 16 0 0 16 0 0 0 0 % H
% Ile: 0 16 0 0 16 0 0 8 8 0 0 0 0 0 16 % I
% Lys: 8 0 8 0 0 0 0 24 0 0 0 0 16 8 0 % K
% Leu: 0 0 0 0 0 77 77 0 16 8 0 0 0 0 0 % L
% Met: 0 0 0 0 0 16 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % N
% Pro: 39 0 0 70 0 0 0 0 62 8 24 70 0 0 0 % P
% Gln: 24 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 70 8 0 0 0 0 % R
% Ser: 0 0 0 0 8 0 0 8 0 0 54 0 0 8 0 % S
% Thr: 0 8 0 24 8 0 0 24 0 0 0 0 8 16 85 % T
% Val: 0 8 16 0 0 0 8 8 8 0 0 0 70 70 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _