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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTIF2
All Species:
27.88
Human Site:
Y449
Identified Species:
51.11
UniProt:
P46199
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46199
NP_001005369.1
727
81317
Y449
E
V
V
D
W
R
K
Y
E
Q
E
Q
E
K
G
Chimpanzee
Pan troglodytes
XP_001155121
727
81419
Y449
E
V
V
D
W
R
K
Y
E
Q
E
Q
E
K
G
Rhesus Macaque
Macaca mulatta
XP_001114893
671
74635
E409
E
D
V
K
I
I
E
E
K
R
K
E
H
Q
E
Dog
Lupus familis
XP_531830
727
81467
Y449
A
V
V
D
W
R
K
Y
E
Q
E
Q
E
K
N
Cat
Felis silvestris
Mouse
Mus musculus
Q91YJ5
727
81328
S449
E
V
I
E
W
R
K
S
E
Q
K
E
E
K
G
Rat
Rattus norvegicus
NP_001004254
727
81236
S449
E
V
V
D
W
R
K
S
E
Q
K
E
E
K
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510159
744
83619
Y467
E
V
I
D
W
R
K
Y
V
E
D
Q
E
K
M
Chicken
Gallus gallus
XP_419288
726
81476
Y449
E
V
V
A
W
R
T
Y
V
E
Q
Q
E
K
M
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001082793
705
78636
Y427
E
V
V
E
W
R
S
Y
M
E
E
Q
D
K
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651621
696
76771
H431
A
V
L
K
Y
R
E
H
E
S
Q
Q
E
K
I
Honey Bee
Apis mellifera
NP_001011586
690
78106
K414
E
V
I
K
F
R
Q
K
Q
R
A
E
I
L
A
Nematode Worm
Caenorhab. elegans
NP_001023936
702
78116
I425
Q
K
A
V
N
L
R
I
D
N
M
M
R
E
K
Sea Urchin
Strong. purpuratus
XP_001180329
739
82065
E466
E
V
V
K
W
R
E
E
R
A
S
T
S
K
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
85.1
85.1
N.A.
81.2
83.3
N.A.
70
65.8
N.A.
57.6
N.A.
45.9
40.8
40.1
47.9
Protein Similarity:
100
99.8
89.4
92
N.A.
90.9
92.3
N.A.
82.3
80.6
N.A.
74.6
N.A.
63
60.5
59.4
65.7
P-Site Identity:
100
100
13.3
86.6
N.A.
66.6
80
N.A.
66.6
60
N.A.
60
N.A.
40
20
0
40
P-Site Similarity:
100
100
53.3
86.6
N.A.
93.3
93.3
N.A.
86.6
73.3
N.A.
80
N.A.
73.3
60
26.6
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
8
8
0
0
0
0
0
8
8
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
39
0
0
0
0
8
0
8
0
8
0
0
% D
% Glu:
77
0
0
16
0
0
24
16
47
24
31
31
62
8
8
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
31
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% H
% Ile:
0
0
24
0
8
8
0
8
0
0
0
0
8
0
8
% I
% Lys:
0
8
0
31
0
0
47
8
8
0
24
0
0
77
8
% K
% Leu:
0
0
8
0
0
8
0
0
0
0
0
0
0
8
16
% L
% Met:
0
0
0
0
0
0
0
0
8
0
8
8
0
0
16
% M
% Asn:
0
0
0
0
8
0
0
0
0
8
0
0
0
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
0
0
0
0
0
8
0
8
39
16
54
0
8
0
% Q
% Arg:
0
0
0
0
0
85
8
0
8
16
0
0
8
0
0
% R
% Ser:
0
0
0
0
0
0
8
16
0
8
8
0
8
0
0
% S
% Thr:
0
0
0
0
0
0
8
0
0
0
0
8
0
0
0
% T
% Val:
0
85
62
8
0
0
0
0
16
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
70
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
47
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _