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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTIF2
All Species:
46.36
Human Site:
Y538
Identified Species:
85
UniProt:
P46199
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46199
NP_001005369.1
727
81317
Y538
I
L
N
I
I
D
T
Y
D
A
S
H
E
C
E
Chimpanzee
Pan troglodytes
XP_001155121
727
81419
Y538
I
L
N
I
I
D
T
Y
D
A
S
H
E
C
E
Rhesus Macaque
Macaca mulatta
XP_001114893
671
74635
Y482
I
L
N
I
I
D
T
Y
D
A
S
H
E
C
E
Dog
Lupus familis
XP_531830
727
81467
Y538
I
V
D
I
M
N
T
Y
D
A
S
H
E
C
E
Cat
Felis silvestris
Mouse
Mus musculus
Q91YJ5
727
81328
Y538
I
L
N
L
L
D
T
Y
D
A
S
H
E
C
E
Rat
Rattus norvegicus
NP_001004254
727
81236
Y538
I
L
N
L
L
D
T
Y
D
A
S
H
E
C
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510159
744
83619
Y556
I
L
N
I
I
D
S
Y
D
A
A
D
E
C
E
Chicken
Gallus gallus
XP_419288
726
81476
Y538
I
L
N
V
L
D
S
Y
D
A
D
D
E
C
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001082793
705
78636
Y516
L
L
N
I
L
E
S
Y
D
A
D
D
Q
C
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651621
696
76771
Y511
I
L
D
V
L
E
T
Y
N
S
N
E
S
C
R
Honey Bee
Apis mellifera
NP_001011586
690
78106
Y501
L
L
D
I
F
D
T
Y
T
Y
D
T
I
C
Q
Nematode Worm
Caenorhab. elegans
NP_001023936
702
78116
Y512
I
L
E
I
L
S
T
Y
K
S
E
Q
C
K
L
Sea Urchin
Strong. purpuratus
XP_001180329
739
82065
Y551
I
L
D
T
L
S
T
Y
T
A
H
H
Q
C
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
85.1
85.1
N.A.
81.2
83.3
N.A.
70
65.8
N.A.
57.6
N.A.
45.9
40.8
40.1
47.9
Protein Similarity:
100
99.8
89.4
92
N.A.
90.9
92.3
N.A.
82.3
80.6
N.A.
74.6
N.A.
63
60.5
59.4
65.7
P-Site Identity:
100
100
100
73.3
N.A.
86.6
86.6
N.A.
80
60
N.A.
46.6
N.A.
33.3
40
33.3
46.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
86.6
N.A.
80
N.A.
80
60
46.6
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
77
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
8
93
0
% C
% Asp:
0
0
31
0
0
62
0
0
70
0
24
24
0
0
0
% D
% Glu:
0
0
8
0
0
16
0
0
0
0
8
8
62
0
54
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
8
54
0
0
0
% H
% Ile:
85
0
0
62
31
0
0
0
0
0
0
0
8
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
8
0
0
0
0
8
16
% K
% Leu:
16
93
0
16
54
0
0
0
0
0
0
0
0
0
16
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
62
0
0
8
0
0
8
0
8
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
8
16
0
8
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% R
% Ser:
0
0
0
0
0
16
24
0
0
16
47
0
8
0
0
% S
% Thr:
0
0
0
8
0
0
77
0
16
0
0
8
0
0
0
% T
% Val:
0
8
0
16
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
100
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _