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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NSF All Species: 46.67
Human Site: S538 Identified Species: 73.33
UniProt: P46459 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P46459 NP_006169.2 744 82594 S538 S D R T P L V S V L L E G P P
Chimpanzee Pan troglodytes XP_511626 842 92301 S611 S D R T P L V S V L L E G P P
Rhesus Macaque Macaca mulatta XP_001105450 854 93325 S648 S D R T P L V S V L L E G P P
Dog Lupus familis XP_548044 752 83541 S538 S D R T P L V S V L L E G P P
Cat Felis silvestris
Mouse Mus musculus P46460 744 82595 S538 S D R T P L V S V L L E G P P
Rat Rattus norvegicus Q9QUL6 744 82634 S538 S D R T P L V S V L L E G P P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_418094 740 82158 S538 S D R T P L V S V L L E G P P
Frog Xenopus laevis P23787 805 89193 K512 K F G M T P S K G V L F Y G P
Zebra Danio Brachydanio rerio Q7ZU99 806 89405 K512 K F G M T P S K G V L F Y G P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P46461 745 82537 S538 P E S S G L V S V L V A G A P
Honey Bee Apis mellifera XP_001120201 743 82591 S541 T E G S G L V S V L L E G P P
Nematode Worm Caenorhab. elegans Q94392 824 91316 T615 P E N S G F R T V V L A G A A
Sea Urchin Strong. purpuratus NP_999752 746 82671 S542 S D R V P L A S M L M G G R S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M0Y8 742 81469 T532 S T R S P L V T C L L E G P S
Baker's Yeast Sacchar. cerevisiae P18759 758 84038 S559 S D K S R L V S L L I H G P A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 88 86.8 98.1 N.A. 98.1 97.8 N.A. N.A. 93.6 26.2 25 N.A. 62.4 65.8 50.6 64.8
Protein Similarity: 100 88.2 87.1 98.8 N.A. 99.7 99.7 N.A. N.A. 96.5 44.2 44.4 N.A. 77.7 81.1 66.2 80.5
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 13.3 13.3 N.A. 46.6 66.6 20 53.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 20 20 N.A. 66.6 86.6 46.6 66.6
Percent
Protein Identity: N.A. N.A. N.A. 43.5 44.9 N.A.
Protein Similarity: N.A. N.A. N.A. 64.6 64.2 N.A.
P-Site Identity: N.A. N.A. N.A. 66.6 53.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 80 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 7 0 0 0 0 14 0 14 14 % A
% Cys: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % C
% Asp: 0 60 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 20 0 0 0 0 0 0 0 0 0 60 0 0 0 % E
% Phe: 0 14 0 0 0 7 0 0 0 0 0 14 0 0 0 % F
% Gly: 0 0 20 0 20 0 0 0 14 0 0 7 87 14 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % I
% Lys: 14 0 7 0 0 0 0 14 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 80 0 0 7 80 80 0 0 0 0 % L
% Met: 0 0 0 14 0 0 0 0 7 0 7 0 0 0 0 % M
% Asn: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 14 0 0 0 60 14 0 0 0 0 0 0 0 67 74 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 60 0 7 0 7 0 0 0 0 0 0 7 0 % R
% Ser: 67 0 7 34 0 0 14 74 0 0 0 0 0 0 14 % S
% Thr: 7 7 0 47 14 0 0 14 0 0 0 0 0 0 0 % T
% Val: 0 0 0 7 0 0 74 0 67 20 7 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 14 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _