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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NSF All Species: 43.33
Human Site: T534 Identified Species: 68.1
UniProt: P46459 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P46459 NP_006169.2 744 82594 T534 Q T K N S D R T P L V S V L L
Chimpanzee Pan troglodytes XP_511626 842 92301 T607 Q T K N S D R T P L V S V L L
Rhesus Macaque Macaca mulatta XP_001105450 854 93325 T644 Q T K N S D R T P L V S V L L
Dog Lupus familis XP_548044 752 83541 T534 Q T K N S D R T P L V S V L L
Cat Felis silvestris
Mouse Mus musculus P46460 744 82595 T534 Q T K N S D R T P L V S V L L
Rat Rattus norvegicus Q9QUL6 744 82634 T534 Q T K N S D R T P L V S V L L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_418094 740 82158 T534 Q T K N S D R T P L V S V L L
Frog Xenopus laevis P23787 805 89193 M508 D K F L K F G M T P S K G V L
Zebra Danio Brachydanio rerio Q7ZU99 806 89405 M508 D K F L K F G M T P S K G V L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P46461 745 82537 S534 Q A K A P E S S G L V S V L V
Honey Bee Apis mellifera XP_001120201 743 82591 S537 E A R S T E G S G L V S V L L
Nematode Worm Caenorhab. elegans Q94392 824 91316 S611 T V K N P E N S G F R T V V L
Sea Urchin Strong. purpuratus NP_999752 746 82671 V538 Q T K A S D R V P L A S M L M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M0Y8 742 81469 S528 Q V K V S T R S P L V T C L L
Baker's Yeast Sacchar. cerevisiae P18759 758 84038 S555 Q V R E S D K S R L V S L L I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 88 86.8 98.1 N.A. 98.1 97.8 N.A. N.A. 93.6 26.2 25 N.A. 62.4 65.8 50.6 64.8
Protein Similarity: 100 88.2 87.1 98.8 N.A. 99.7 99.7 N.A. N.A. 96.5 44.2 44.4 N.A. 77.7 81.1 66.2 80.5
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 6.6 6.6 N.A. 46.6 40 26.6 66.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 13.3 13.3 N.A. 66.6 80 53.3 80
Percent
Protein Identity: N.A. N.A. N.A. 43.5 44.9 N.A.
Protein Similarity: N.A. N.A. N.A. 64.6 64.2 N.A.
P-Site Identity: N.A. N.A. N.A. 60 46.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 73.3 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 14 0 14 0 0 0 0 0 0 7 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % C
% Asp: 14 0 0 0 0 60 0 0 0 0 0 0 0 0 0 % D
% Glu: 7 0 0 7 0 20 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 14 0 0 14 0 0 0 7 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 20 0 20 0 0 0 14 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % I
% Lys: 0 14 74 0 14 0 7 0 0 0 0 14 0 0 0 % K
% Leu: 0 0 0 14 0 0 0 0 0 80 0 0 7 80 80 % L
% Met: 0 0 0 0 0 0 0 14 0 0 0 0 7 0 7 % M
% Asn: 0 0 0 54 0 0 7 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 14 0 0 0 60 14 0 0 0 0 0 % P
% Gln: 74 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 14 0 0 0 60 0 7 0 7 0 0 0 0 % R
% Ser: 0 0 0 7 67 0 7 34 0 0 14 74 0 0 0 % S
% Thr: 7 54 0 0 7 7 0 47 14 0 0 14 0 0 0 % T
% Val: 0 20 0 7 0 0 0 7 0 0 74 0 67 20 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _