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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NSF
All Species:
27.27
Human Site:
Y502
Identified Species:
42.86
UniProt:
P46459
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46459
NP_006169.2
744
82594
Y502
N
Q
E
D
Y
A
S
Y
I
M
N
G
I
I
K
Chimpanzee
Pan troglodytes
XP_511626
842
92301
Y575
N
Q
E
D
Y
A
S
Y
I
M
N
G
I
I
K
Rhesus Macaque
Macaca mulatta
XP_001105450
854
93325
Y612
N
Q
E
D
Y
A
S
Y
I
M
N
G
I
I
K
Dog
Lupus familis
XP_548044
752
83541
Y502
N
Q
E
D
Y
A
S
Y
I
M
N
G
I
I
K
Cat
Felis silvestris
Mouse
Mus musculus
P46460
744
82595
Y502
N
Q
E
D
Y
A
S
Y
I
M
N
G
I
I
K
Rat
Rattus norvegicus
Q9QUL6
744
82634
Y502
N
Q
E
D
Y
A
S
Y
I
M
N
G
I
I
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_418094
740
82158
Y502
N
Q
E
D
Y
A
S
Y
I
M
N
G
I
I
K
Frog
Xenopus laevis
P23787
805
89193
W476
V
E
V
P
Q
V
T
W
E
D
I
G
G
L
E
Zebra Danio
Brachydanio rerio
Q7ZU99
806
89405
W476
V
E
V
P
N
I
T
W
E
D
I
G
G
L
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P46461
745
82537
M502
A
Q
E
I
L
D
N
M
L
A
R
G
V
I
N
Honey Bee
Apis mellifera
XP_001120201
743
82591
L505
S
A
E
A
L
D
Y
L
L
I
R
G
I
I
N
Nematode Worm
Caenorhab. elegans
Q94392
824
91316
F579
S
D
E
S
L
N
R
F
L
S
R
G
M
I
V
Sea Urchin
Strong. purpuratus
NP_999752
746
82671
F506
S
S
E
N
F
D
K
F
I
L
N
G
I
I
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9M0Y8
742
81469
C496
S
T
D
D
L
E
R
C
R
L
N
G
M
V
D
Baker's Yeast
Sacchar. cerevisiae
P18759
758
84038
C523
S
E
E
D
L
K
T
C
V
E
G
G
M
M
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88
86.8
98.1
N.A.
98.1
97.8
N.A.
N.A.
93.6
26.2
25
N.A.
62.4
65.8
50.6
64.8
Protein Similarity:
100
88.2
87.1
98.8
N.A.
99.7
99.7
N.A.
N.A.
96.5
44.2
44.4
N.A.
77.7
81.1
66.2
80.5
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
6.6
6.6
N.A.
26.6
26.6
20
40
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
40
33.3
N.A.
46.6
46.6
46.6
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.5
44.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
64.6
64.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
7
0
47
0
0
0
7
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
14
0
0
0
0
0
0
0
% C
% Asp:
0
7
7
60
0
20
0
0
0
14
0
0
0
0
20
% D
% Glu:
0
20
80
0
0
7
0
0
14
7
0
0
0
0
7
% E
% Phe:
0
0
0
0
7
0
0
14
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
7
100
14
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
7
0
7
0
0
54
7
14
0
60
74
0
% I
% Lys:
0
0
0
0
0
7
7
0
0
0
0
0
0
0
47
% K
% Leu:
0
0
0
0
34
0
0
7
20
14
0
0
0
14
7
% L
% Met:
0
0
0
0
0
0
0
7
0
47
0
0
20
7
0
% M
% Asn:
47
0
0
7
7
7
7
0
0
0
60
0
0
0
14
% N
% Pro:
0
0
0
14
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
54
0
0
7
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
14
0
7
0
20
0
0
0
0
% R
% Ser:
34
7
0
7
0
0
47
0
0
7
0
0
0
0
0
% S
% Thr:
0
7
0
0
0
0
20
0
0
0
0
0
0
0
0
% T
% Val:
14
0
14
0
0
7
0
0
7
0
0
0
7
7
7
% V
% Trp:
0
0
0
0
0
0
0
14
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
47
0
7
47
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _