KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH1
All Species:
29.7
Human Site:
S1856
Identified Species:
54.44
UniProt:
P46531
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46531
NP_060087.3
2555
272505
S1856
D
A
A
D
L
R
M
S
A
M
A
P
T
P
P
Chimpanzee
Pan troglodytes
XP_520371
2555
272693
S1856
D
A
A
D
L
R
M
S
A
M
A
P
T
P
P
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
T1802
E
A
A
D
I
R
R
T
P
S
L
A
L
T
P
Dog
Lupus familis
XP_537795
2544
270793
S1825
D
A
A
D
L
R
V
S
A
M
A
P
T
P
P
Cat
Felis silvestris
Mouse
Mus musculus
Q01705
2531
271296
S1846
D
A
A
D
L
R
M
S
A
M
A
P
T
P
P
Rat
Rattus norvegicus
Q07008
2531
270981
S1846
D
A
A
D
L
R
V
S
A
M
A
P
T
P
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
A1798
E
A
A
D
I
R
R
A
P
S
L
A
L
T
P
Chicken
Gallus gallus
XP_415420
2590
279561
S1895
D
A
A
D
L
R
I
S
S
M
A
P
T
P
P
Frog
Xenopus laevis
P21783
2524
275106
S1852
D
A
A
D
L
R
I
S
S
M
A
P
T
P
P
Zebra Danio
Brachydanio rerio
P46530
2437
262289
K1788
S
V
G
L
K
P
L
K
N
S
D
S
S
L
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
I1881
D
V
V
D
V
R
A
I
M
T
P
P
A
H
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
E798
V
R
I
Q
R
D
E
E
G
P
L
V
F
Q
W
Sea Urchin
Strong. purpuratus
P10079
1064
112055
G433
Y
V
C
I
C
A
P
G
F
D
G
L
N
C
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
53.1
89.5
N.A.
89.3
90.2
N.A.
51.3
79.6
74.3
67.7
N.A.
44.4
N.A.
20.5
21.6
Protein Similarity:
100
99.8
66.5
93.7
N.A.
93
94
N.A.
63.6
87.6
85.2
78.7
N.A.
58.6
N.A.
33.3
29.4
P-Site Identity:
100
100
33.3
93.3
N.A.
100
93.3
N.A.
33.3
86.6
86.6
0
N.A.
26.6
N.A.
0
0
P-Site Similarity:
100
100
53.3
100
N.A.
100
100
N.A.
53.3
100
100
13.3
N.A.
33.3
N.A.
0
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
70
70
0
0
8
8
8
39
0
54
16
8
0
0
% A
% Cys:
0
0
8
0
8
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
62
0
0
77
0
8
0
0
0
8
8
0
0
0
0
% D
% Glu:
16
0
0
0
0
0
8
8
0
0
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
8
0
0
0
8
0
0
% F
% Gly:
0
0
8
0
0
0
0
8
8
0
8
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
0
8
8
16
0
16
8
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
8
0
0
8
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
8
54
0
8
0
0
0
24
8
16
8
0
% L
% Met:
0
0
0
0
0
0
24
0
8
54
0
0
0
0
8
% M
% Asn:
0
0
0
0
0
0
0
0
8
0
0
0
8
0
0
% N
% Pro:
0
0
0
0
0
8
8
0
16
8
8
62
0
54
70
% P
% Gln:
0
0
0
8
0
0
0
0
0
0
0
0
0
8
8
% Q
% Arg:
0
8
0
0
8
77
16
0
0
0
0
0
0
0
0
% R
% Ser:
8
0
0
0
0
0
0
54
16
24
0
8
8
0
0
% S
% Thr:
0
0
0
0
0
0
0
8
0
8
0
0
54
16
0
% T
% Val:
8
24
8
0
8
0
16
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _