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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NOTCH1 All Species: 25.45
Human Site: S2141 Identified Species: 46.67
UniProt: P46531 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P46531 NP_060087.3 2555 272505 S2141 T L S P P L C S P N G Y L G S
Chimpanzee Pan troglodytes XP_520371 2555 272693 S2141 T L S P P L C S P N G Y L G S
Rhesus Macaque Macaca mulatta XP_001114248 2471 265649 A2079 P G T V L T S A L S P V I C G
Dog Lupus familis XP_537795 2544 270793 S2110 T L S P P L C S P N G Y L G N
Cat Felis silvestris
Mouse Mus musculus Q01705 2531 271296 S2130 T L S P T L C S P N G Y P G N
Rat Rattus norvegicus Q07008 2531 270981 S2131 T L S P T L C S P N G Y L G N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512292 2467 261963 S2077 T V L A A A L S P A A L C G P
Chicken Gallus gallus XP_415420 2590 279561 S2179 T L S P P L C S P S S Y I G N
Frog Xenopus laevis P21783 2524 275106 S2132 P L G A T T L S P P I C S P N
Zebra Danio Brachydanio rerio P46530 2437 262289 L2035 N V D A A V V L L K N G A N K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07207 2703 288835 Q2164 S P P P G Q Q Q P Q L I T Q P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P14585 1429 157097 T1041 Y A I T E P I T R E S V N I I
Sea Urchin Strong. purpuratus P10079 1064 112055 S676 T E I D E C A S S P C L N G G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 53.1 89.5 N.A. 89.3 90.2 N.A. 51.3 79.6 74.3 67.7 N.A. 44.4 N.A. 20.5 21.6
Protein Similarity: 100 99.8 66.5 93.7 N.A. 93 94 N.A. 63.6 87.6 85.2 78.7 N.A. 58.6 N.A. 33.3 29.4
P-Site Identity: 100 100 0 93.3 N.A. 80 86.6 N.A. 26.6 73.3 20 0 N.A. 13.3 N.A. 0 20
P-Site Similarity: 100 100 26.6 100 N.A. 86.6 93.3 N.A. 33.3 93.3 26.6 13.3 N.A. 20 N.A. 6.6 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 24 16 8 8 8 0 8 8 0 8 0 0 % A
% Cys: 0 0 0 0 0 8 47 0 0 0 8 8 8 8 0 % C
% Asp: 0 0 8 8 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 8 0 0 16 0 0 0 0 8 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 8 8 0 8 0 0 0 0 0 39 8 0 62 16 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 16 0 0 0 8 0 0 0 8 8 16 8 8 % I
% Lys: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 8 % K
% Leu: 0 54 8 0 8 47 16 8 16 0 8 16 31 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 0 0 0 0 0 0 39 8 0 16 8 39 % N
% Pro: 16 8 8 54 31 8 0 0 70 16 8 0 8 8 16 % P
% Gln: 0 0 0 0 0 8 8 8 0 8 0 0 0 8 0 % Q
% Arg: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % R
% Ser: 8 0 47 0 0 0 8 70 8 16 16 0 8 0 16 % S
% Thr: 62 0 8 8 24 16 0 8 0 0 0 0 8 0 0 % T
% Val: 0 16 0 8 0 8 8 0 0 0 0 16 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 0 0 0 0 47 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _