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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH1
All Species:
4.55
Human Site:
S2148
Identified Species:
8.33
UniProt:
P46531
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46531
NP_060087.3
2555
272505
S2148
S
P
N
G
Y
L
G
S
L
K
P
G
V
Q
G
Chimpanzee
Pan troglodytes
XP_520371
2555
272693
S2148
S
P
N
G
Y
L
G
S
L
K
P
G
V
Q
G
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
G2086
A
L
S
P
V
I
C
G
P
N
R
S
F
L
S
Dog
Lupus familis
XP_537795
2544
270793
N2117
S
P
N
G
Y
L
G
N
L
K
P
S
V
P
G
Cat
Felis silvestris
Mouse
Mus musculus
Q01705
2531
271296
N2137
S
P
N
G
Y
P
G
N
L
K
S
A
T
Q
G
Rat
Rattus norvegicus
Q07008
2531
270981
N2138
S
P
N
G
Y
L
G
N
L
K
S
A
T
Q
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
P2084
S
P
A
A
L
C
G
P
N
R
P
F
L
N
L
Chicken
Gallus gallus
XP_415420
2590
279561
N2186
S
P
S
S
Y
I
G
N
L
K
P
A
V
Q
G
Frog
Xenopus laevis
P21783
2524
275106
N2139
S
P
P
I
C
S
P
N
G
Y
M
G
N
M
K
Zebra Danio
Brachydanio rerio
P46530
2437
262289
K2042
L
L
K
N
G
A
N
K
D
L
Q
N
N
K
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
P2171
Q
P
Q
L
I
T
Q
P
T
V
I
S
A
G
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
I1048
T
R
E
S
V
N
I
I
D
P
R
H
N
R
T
Sea Urchin
Strong. purpuratus
P10079
1064
112055
G683
S
S
P
C
L
N
G
G
Q
C
I
D
R
V
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
53.1
89.5
N.A.
89.3
90.2
N.A.
51.3
79.6
74.3
67.7
N.A.
44.4
N.A.
20.5
21.6
Protein Similarity:
100
99.8
66.5
93.7
N.A.
93
94
N.A.
63.6
87.6
85.2
78.7
N.A.
58.6
N.A.
33.3
29.4
P-Site Identity:
100
100
0
80
N.A.
66.6
73.3
N.A.
26.6
66.6
20
0
N.A.
6.6
N.A.
0
13.3
P-Site Similarity:
100
100
20
86.6
N.A.
73.3
80
N.A.
40
86.6
26.6
6.6
N.A.
6.6
N.A.
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
8
0
8
0
0
0
0
0
24
8
0
0
% A
% Cys:
0
0
0
8
8
8
8
0
0
8
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
16
0
0
8
0
0
8
% D
% Glu:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
8
8
0
0
% F
% Gly:
0
0
0
39
8
0
62
16
8
0
0
24
0
8
47
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
0
8
8
16
8
8
0
0
16
0
0
0
0
% I
% Lys:
0
0
8
0
0
0
0
8
0
47
0
0
0
8
8
% K
% Leu:
8
16
0
8
16
31
0
0
47
8
0
0
8
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
0
% M
% Asn:
0
0
39
8
0
16
8
39
8
8
0
8
24
8
8
% N
% Pro:
0
70
16
8
0
8
8
16
8
8
39
0
0
8
0
% P
% Gln:
8
0
8
0
0
0
8
0
8
0
8
0
0
39
0
% Q
% Arg:
0
8
0
0
0
0
0
0
0
8
16
0
8
8
0
% R
% Ser:
70
8
16
16
0
8
0
16
0
0
16
24
0
0
8
% S
% Thr:
8
0
0
0
0
8
0
0
8
0
0
0
16
0
8
% T
% Val:
0
0
0
0
16
0
0
0
0
8
0
0
31
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
47
0
0
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _