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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NOTCH1 All Species: 17.27
Human Site: S2202 Identified Species: 31.67
UniProt: P46531 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P46531 NP_060087.3 2555 272505 S2202 G M L S P V D S L E S P H G Y
Chimpanzee Pan troglodytes XP_520371 2555 272693 S2202 G M L S P V D S L E S P H G Y
Rhesus Macaque Macaca mulatta XP_001114248 2471 265649 Q2140 K S L S E K V Q L S E S S V T
Dog Lupus familis XP_537795 2544 270793 S2171 S V L S P V D S L E S P H G Y
Cat Felis silvestris
Mouse Mus musculus Q01705 2531 271296 D2191 S S M L S P V D S L E S P H G
Rat Rattus norvegicus Q07008 2531 270981 S2192 S M L S P V D S L E S P H G Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512292 2467 261963 Q2138 K N L G E K G Q L S E S S V T
Chicken Gallus gallus XP_415420 2590 279561 S2240 S V L S P V D S L E S P H G Y
Frog Xenopus laevis P21783 2524 275106 L2193 D S G S S G V L S P V D S L E
Zebra Danio Brachydanio rerio P46530 2437 262289 D2096 A H E R M H H D I V R L L E E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07207 2703 288835 A2225 T G S L R R K A S S K K T S A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P14585 1429 157097 V1102 N T P L M L A V L A R R R R L
Sea Urchin Strong. purpuratus P10079 1064 112055 G737 Y V C N C A P G Y T G D N C E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 53.1 89.5 N.A. 89.3 90.2 N.A. 51.3 79.6 74.3 67.7 N.A. 44.4 N.A. 20.5 21.6
Protein Similarity: 100 99.8 66.5 93.7 N.A. 93 94 N.A. 63.6 87.6 85.2 78.7 N.A. 58.6 N.A. 33.3 29.4
P-Site Identity: 100 100 20 86.6 N.A. 0 93.3 N.A. 13.3 86.6 6.6 0 N.A. 0 N.A. 6.6 0
P-Site Similarity: 100 100 20 93.3 N.A. 6.6 93.3 N.A. 13.3 93.3 6.6 6.6 N.A. 6.6 N.A. 13.3 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 8 8 8 0 8 0 0 0 0 8 % A
% Cys: 0 0 8 0 8 0 0 0 0 0 0 0 0 8 0 % C
% Asp: 8 0 0 0 0 0 39 16 0 0 0 16 0 0 0 % D
% Glu: 0 0 8 0 16 0 0 0 0 39 24 0 0 8 24 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 16 8 8 8 0 8 8 8 0 0 8 0 0 39 8 % G
% His: 0 8 0 0 0 8 8 0 0 0 0 0 39 8 0 % H
% Ile: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % I
% Lys: 16 0 0 0 0 16 8 0 0 0 8 8 0 0 0 % K
% Leu: 0 0 54 24 0 8 0 8 62 8 0 8 8 8 8 % L
% Met: 0 24 8 0 16 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 8 0 8 0 0 0 0 0 0 0 0 8 0 0 % N
% Pro: 0 0 8 0 39 8 8 0 0 8 0 39 8 0 0 % P
% Gln: 0 0 0 0 0 0 0 16 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 8 8 8 0 0 0 0 16 8 8 8 0 % R
% Ser: 31 24 8 54 16 0 0 39 24 24 39 24 24 8 0 % S
% Thr: 8 8 0 0 0 0 0 0 0 8 0 0 8 0 16 % T
% Val: 0 24 0 0 0 39 24 8 0 8 8 0 0 16 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 0 8 0 0 0 0 0 39 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _