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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NOTCH1 All Species: 12.73
Human Site: S2364 Identified Species: 23.33
UniProt: P46531 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P46531 NP_060087.3 2555 272505 S2364 S A L S Q M M S Y Q G L P S T
Chimpanzee Pan troglodytes XP_520371 2555 272693 S2364 S A L S Q M M S Y Q G L P S T
Rhesus Macaque Macaca mulatta XP_001114248 2471 265649 E2290 A P Q S R P P E G K H I T T P
Dog Lupus familis XP_537795 2544 270793 M2340 T A A L S H M M S Y Q A L P N
Cat Felis silvestris
Mouse Mus musculus Q01705 2531 271296 T2346 P L H S S L S T N T L S P I I
Rat Rattus norvegicus Q07008 2531 270981 T2346 P I H S S L S T N T L S P I I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512292 2467 261963 G2287 T G P G Q P D G K Q A A T S S
Chicken Gallus gallus XP_415420 2590 279561 S2396 T S L S Q M M S Y Q A M P S T
Frog Xenopus laevis P21783 2524 275106 G2342 L M T S L H N G L P A T T L S
Zebra Danio Brachydanio rerio P46530 2437 262289 N2249 S H L P V A N N V G G A Q A G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07207 2703 288835 S2514 G I I S P T G S D M G I M L A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P14585 1429 157097 E1251 P I M L A A Q E G R I E V V M
Sea Urchin Strong. purpuratus P10079 1064 112055 C886 G A D Y V C E C V P G Y A G Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 53.1 89.5 N.A. 89.3 90.2 N.A. 51.3 79.6 74.3 67.7 N.A. 44.4 N.A. 20.5 21.6
Protein Similarity: 100 99.8 66.5 93.7 N.A. 93 94 N.A. 63.6 87.6 85.2 78.7 N.A. 58.6 N.A. 33.3 29.4
P-Site Identity: 100 100 6.6 13.3 N.A. 13.3 13.3 N.A. 20 73.3 6.6 20 N.A. 20 N.A. 0 13.3
P-Site Similarity: 100 100 40 20 N.A. 26.6 26.6 N.A. 33.3 93.3 13.3 33.3 N.A. 33.3 N.A. 13.3 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 31 8 0 8 16 0 0 0 0 24 24 8 8 8 % A
% Cys: 0 0 0 0 0 8 0 8 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 0 0 0 8 0 8 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 8 16 0 0 0 8 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 16 8 0 8 0 0 8 16 16 8 39 0 0 8 8 % G
% His: 0 8 16 0 0 16 0 0 0 0 8 0 0 0 0 % H
% Ile: 0 24 8 0 0 0 0 0 0 0 8 16 0 16 16 % I
% Lys: 0 0 0 0 0 0 0 0 8 8 0 0 0 0 0 % K
% Leu: 8 8 31 16 8 16 0 0 8 0 16 16 8 16 0 % L
% Met: 0 8 8 0 0 24 31 8 0 8 0 8 8 0 8 % M
% Asn: 0 0 0 0 0 0 16 8 16 0 0 0 0 0 8 % N
% Pro: 24 8 8 8 8 16 8 0 0 16 0 0 39 8 8 % P
% Gln: 0 0 8 0 31 0 8 0 0 31 8 0 8 0 8 % Q
% Arg: 0 0 0 0 8 0 0 0 0 8 0 0 0 0 0 % R
% Ser: 24 8 0 62 24 0 16 31 8 0 0 16 0 31 16 % S
% Thr: 24 0 8 0 0 8 0 16 0 16 0 8 24 8 24 % T
% Val: 0 0 0 0 16 0 0 0 16 0 0 0 8 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 0 0 0 0 24 8 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _