KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH1
All Species:
18.48
Human Site:
S2422
Identified Species:
33.89
UniProt:
P46531
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46531
NP_060087.3
2555
272505
S2422
P
Q
P
H
L
G
V
S
S
A
A
S
G
H
L
Chimpanzee
Pan troglodytes
XP_520371
2555
272693
S2422
P
Q
P
H
L
G
V
S
S
A
A
S
G
H
L
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
T2338
A
V
T
G
P
L
P
T
M
Y
Q
I
P
E
M
Dog
Lupus familis
XP_537795
2544
270793
S2410
P
Q
P
H
L
G
V
S
S
A
A
S
G
H
V
Cat
Felis silvestris
Mouse
Mus musculus
Q01705
2531
271296
S2397
S
Q
P
H
L
S
V
S
S
A
A
N
G
H
L
Rat
Rattus norvegicus
Q07008
2531
270981
S2397
S
Q
P
H
L
S
V
S
S
A
A
N
G
H
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
Y2335
A
G
P
L
G
G
M
Y
Q
I
P
D
L
A
R
Chicken
Gallus gallus
XP_415420
2590
279561
G2457
P
Q
Q
H
H
N
P
G
S
N
A
S
G
H
M
Frog
Xenopus laevis
P21783
2524
275106
H2391
Q
S
M
Q
Q
Q
H
H
N
S
S
T
T
S
T
Zebra Danio
Brachydanio rerio
P46530
2437
262289
A2306
M
Q
S
S
H
L
G
A
P
S
H
M
I
A
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
Q2565
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
L
G
G
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
E1299
I
F
D
R
C
R
P
E
R
E
Y
S
M
D
L
Sea Urchin
Strong. purpuratus
P10079
1064
112055
E934
G
Y
I
G
V
N
C
E
E
V
G
F
C
D
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
53.1
89.5
N.A.
89.3
90.2
N.A.
51.3
79.6
74.3
67.7
N.A.
44.4
N.A.
20.5
21.6
Protein Similarity:
100
99.8
66.5
93.7
N.A.
93
94
N.A.
63.6
87.6
85.2
78.7
N.A.
58.6
N.A.
33.3
29.4
P-Site Identity:
100
100
0
93.3
N.A.
80
80
N.A.
13.3
53.3
0
6.6
N.A.
20
N.A.
13.3
6.6
P-Site Similarity:
100
100
13.3
100
N.A.
86.6
86.6
N.A.
20
60
26.6
20
N.A.
20
N.A.
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
0
0
0
0
0
8
0
39
47
0
0
16
0
% A
% Cys:
0
0
0
0
8
0
8
0
0
0
0
0
8
0
0
% C
% Asp:
0
0
8
0
0
0
0
0
0
0
0
8
0
16
0
% D
% Glu:
0
0
0
0
0
0
0
16
8
8
0
0
0
8
0
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
0
8
0
0
0
% F
% Gly:
8
8
0
16
8
31
8
8
0
0
8
0
54
8
0
% G
% His:
0
0
0
47
16
0
8
8
0
0
8
0
0
47
8
% H
% Ile:
8
0
8
0
0
0
0
0
0
8
0
8
8
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
8
39
16
0
0
0
0
0
8
8
0
54
% L
% Met:
8
0
8
0
0
0
8
0
8
0
0
8
8
0
16
% M
% Asn:
0
0
0
0
0
16
0
0
8
8
0
16
0
0
0
% N
% Pro:
31
0
47
0
8
0
24
0
8
0
8
0
8
0
0
% P
% Gln:
16
62
16
16
16
16
8
8
16
8
16
0
0
0
0
% Q
% Arg:
0
0
0
8
0
8
0
0
8
0
0
0
0
0
8
% R
% Ser:
16
8
8
8
0
16
0
39
47
16
8
39
0
8
0
% S
% Thr:
0
0
8
0
0
0
0
8
0
0
0
8
8
0
8
% T
% Val:
0
8
0
0
8
0
39
0
0
8
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
8
0
8
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _