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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH1
All Species:
17.88
Human Site:
S2432
Identified Species:
32.78
UniProt:
P46531
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46531
NP_060087.3
2555
272505
S2432
A
S
G
H
L
G
R
S
F
L
S
G
E
P
S
Chimpanzee
Pan troglodytes
XP_520371
2555
272693
S2432
A
S
G
H
L
G
R
S
F
L
S
G
E
P
S
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
L2348
Q
I
P
E
M
A
R
L
P
S
V
A
F
P
T
Dog
Lupus familis
XP_537795
2544
270793
S2420
A
S
G
H
V
G
R
S
F
L
G
G
E
P
S
Cat
Felis silvestris
Mouse
Mus musculus
Q01705
2531
271296
S2407
A
N
G
H
L
G
R
S
F
L
S
G
E
P
S
Rat
Rattus norvegicus
Q07008
2531
270981
S2407
A
N
G
H
L
G
R
S
F
L
S
G
E
P
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
G2345
P
D
L
A
R
M
Q
G
V
A
Y
P
A
A
V
Chicken
Gallus gallus
XP_415420
2590
279561
N2467
A
S
G
H
M
G
Q
N
F
L
G
T
E
L
S
Frog
Xenopus laevis
P21783
2524
275106
N2401
S
T
T
S
T
H
I
N
S
P
F
C
S
S
D
Zebra Danio
Brachydanio rerio
P46530
2437
262289
M2316
H
M
I
A
H
Q
N
M
A
P
M
Q
H
Q
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
G2575
Q
L
G
G
L
E
F
G
S
A
G
L
D
L
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
Q1309
Y
S
M
D
L
H
I
Q
H
T
H
Q
P
Q
P
Sea Urchin
Strong. purpuratus
P10079
1064
112055
M944
G
F
C
D
L
E
G
M
W
Y
N
E
C
N
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
53.1
89.5
N.A.
89.3
90.2
N.A.
51.3
79.6
74.3
67.7
N.A.
44.4
N.A.
20.5
21.6
Protein Similarity:
100
99.8
66.5
93.7
N.A.
93
94
N.A.
63.6
87.6
85.2
78.7
N.A.
58.6
N.A.
33.3
29.4
P-Site Identity:
100
100
13.3
86.6
N.A.
93.3
93.3
N.A.
0
60
0
0
N.A.
13.3
N.A.
13.3
6.6
P-Site Similarity:
100
100
26.6
93.3
N.A.
100
100
N.A.
6.6
80
20
6.6
N.A.
26.6
N.A.
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
47
0
0
16
0
8
0
0
8
16
0
8
8
8
0
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
0
8
8
0
0
% C
% Asp:
0
8
0
16
0
0
0
0
0
0
0
0
8
0
16
% D
% Glu:
0
0
0
8
0
16
0
0
0
0
0
8
47
0
0
% E
% Phe:
0
8
0
0
0
0
8
0
47
0
8
0
8
0
0
% F
% Gly:
8
0
54
8
0
47
8
16
0
0
24
39
0
0
0
% G
% His:
8
0
0
47
8
16
0
0
8
0
8
0
8
0
0
% H
% Ile:
0
8
8
0
0
0
16
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
8
8
0
54
0
0
8
0
47
0
8
0
16
0
% L
% Met:
0
8
8
0
16
8
0
16
0
0
8
0
0
0
0
% M
% Asn:
0
16
0
0
0
0
8
16
0
0
8
0
0
8
16
% N
% Pro:
8
0
8
0
0
0
0
0
8
16
0
8
8
47
8
% P
% Gln:
16
0
0
0
0
8
16
8
0
0
0
16
0
16
0
% Q
% Arg:
0
0
0
0
8
0
47
0
0
0
0
0
0
0
0
% R
% Ser:
8
39
0
8
0
0
0
39
16
8
31
0
8
8
47
% S
% Thr:
0
8
8
0
8
0
0
0
0
8
0
8
0
0
8
% T
% Val:
0
0
0
0
8
0
0
0
8
0
8
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
8
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _